Objective To discuss the significance and gender differences of serum high-sensitivity C-reactive protein in young adults in with ischemic stroke. Methods In this study, a total of 140 young adults including 68 young women and 72 young men with primary acute ischemic stroke who were admitted to the Department of Neurology in Hebei Provincial General Hospial between Feburary, 2004 and Feburary, 2012 were enrolled. Their serum hs-CRP were detected, compared with that of 145 young healthy adults who accepted physical examination at outpatient department during the same period. All these data were tested through one way ANOVA. The women and men in stroke group were respectivly devided into 3 subgroups according to the area of infarction, and the differences of serum hs-CRP among subgroups were analyzed by one way ANOVA. Results There were statistical significances in serum hs-CRP between young ischemic stroke women and young healthy women, and between young ischemic stroke women and young ischemic stroke men ( P <0. 05 ); There was no statistical significance in serum hs-CRP between young stroke man and young healthy men ( P >0. 05 ). There were statistical significances in serum hs-CRP among subgroups of young ischemic stroke women( P <0.05 ). Serum hs-CRP in young men with largre cerebral infarctions was higher than that in young men with lacunar infarctions( P <0. 05 ). Conclusion The level of serum hs-CRP can reflect the degree of cerebral infarction in young adults, and inflammatory mechanism probably has a closer relationship with ischemic stroke in young women.%目的 探讨超敏C-反应蛋白(hs-CRP)在青年缺血性脑卒中患者中的性别差异及其临床意义.方法 分析2004年2月-2012年2月收治的140例汉族青年急性缺血性脑卒中患者的血清hs-CRP水平,其中女性患者68例,男性患者72例,再分别根据病灶大小分为3个亚组;纳入同期门诊查体的145例汉族健康青年为健康对照组.对各组间血清hs-CRP水平进行比较.结果 缺血性脑卒中组女性患者血清hs-CRP水平明显高于健康女性(P<0.05);缺血性脑卒中组男性患者血清hs-CRP水平与健康对照组男性比较差异无统计学意义(P>0.05) ;缺血性脑卒中组女性患者血清hs-CRP水平明显高于男性,差异有统计学意义(P<0.05).女性患者中,大梗死灶亚组血清hs-CRP水平高于小梗死灶亚组,小梗死灶亚组血清hs-CRP水平高于腔隙性梗死灶亚组,差异具有统计学意义(P<0.05);男性患者中,大梗死灶亚组血清hs-CRP水平高于腔隙性梗死灶亚组(P<0.05).结论 血清hs-CRP增高可反映青年缺血性脑卒中患者脑组织缺血坏死的严重程度,且炎性反应机制与青年女性缺血性脑卒中的关系可能更为密切.
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