Chiral aryl sulfonyl hydantoins as hypoglycemic agents

Ahmad R.; Zia-ul-Haq M.; Nadeem H.; Duddeck H.; Verspohl EJ.; Jabeen R.

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Chiral aryl sulfonyl hydantoins as hypoglycemic agents

机译：手性芳基磺酰基乙内酰脲作为降糖药

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Some novel chiral sulfonyl hydantoin derivatives 2a - e and 3a - e have been prepared. p-Toluenesulfonyl chloride on treatment with L-amino acids in presence of K2CO3/H2O yielded N-(p-toluensulfonyl-)amino acids 1a - e which were cyclized in presence of NH4SCN / Ac2O to afford 1-(p-toluenesulfonyl)-5-substituted-2-thiohydantoins 2a - e. These compounds were oxidized with HNO3 to yield 1-(p-toluenesulfonyl)-5-substituted hydantoins 3a-e. The enantiomeric ratios of 3a-e were determined by H-1 NMR spectroscopy using Eu(hfc)(3). The antidiabetic activity of 3a -d has been determined. [References: 14]

机译：已经制备了一些新颖的手性磺酰基乙内酰脲衍生物2a-e和3a-e。在K2CO3 / H2O存在下用L-氨基酸处理的对甲苯磺酰氯产生N-（对甲苯磺酰基-）氨基酸1a-e，在NH4SCN / Ac2O存在下环化，得到1-（对甲苯磺酰基）- 5-取代的2-硫代乙内酰脲2a-e。这些化合物用HNO 3氧化，得到1-（对甲苯磺酰基）-5-取代的乙内酰脲3a-e。通过使用Eu（hfc）（3）的H-1 NMR光谱确定3a-e的对映体比率。已经确定了3a-d的抗糖尿病活性。 [参考：14]

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《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |2000年第2期|共5页
作者
Ahmad R.; Zia-ul-Haq M.; Nadeem H.; Duddeck H.; Verspohl EJ.; Jabeen R.;
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正文语种 eng
中图分类化学;
关键词
Hydantoins; Antidiabetic activity; Nmr data; Pure;

机译：乙内酰脲;抗糖尿病活性;Nmr数据;纯;

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1. Chiral aryl sulfonyl hydantoins as hypoglycemic agents [J] . Ahmad R., Zia-ul-Haq M., Nadeem H., Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 2000,第2期

机译：手性芳基磺酰基乙内酰脲作为降糖药
2. Synthesis of 2-Aryl and 3-Aryl Benzo[b]furan Thioethers Using Aryl Sulfonyl Hydrazides as Sulfenylation Reagents [J] . Zhao Xia, Zhang Lipeng, Lu Xiaoyu, The Journal of Organic Chemistry . 2015,第5期

机译：以芳基磺酰肼为亚磺酰基化试剂合成2-芳基和3-芳基苯并[b]呋喃硫醚
3. Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents [J] . Andreou Nicolaos-Panagiotis, Dafnopoulos Konstantinos, Tortopidis Christos, Journal of Photochemistry and Photobiology, B. Biology: Official Journal of the European Society for Photobiology . 2016,第Null期

机译：烷基和芳基磺酰基对吡啶乙酮肟是有效的DNA光裂解剂
4. Treatment of noninsulin-dependent diabetes mellitus with oral hypoglycemic agents [C] . Deborah S. Greco DVM, PhD, Dacvim fort collins, Annual Veterinary Medical Forum . 1997

机译：用口服降血糖药物治疗非胰岛素依赖性糖尿病
5. I. Tertiary aryl sulfonamides as new cross coupling partners for nickel catalyzed Kumada-Corriu-Tamao reductive and carbon-carbon bond forming cross coupling reactions. II. N-sulfonyl deprotection under mild nickel(0) catalyzed Kumada-Corriu-Tamao coupling conditions and development of the N-Ans protecting group. III. Synthesis and application of 3,3'-di-(2-pyridyl)-1,1'-bi-2-naphthol ligands [D] . Milburn, Robert Ronald 2004

机译：I.叔芳基磺酰胺作为镍催化的Kumada-Corriu-Tamao还原和碳-碳键形成交叉偶联反应的新交叉偶联伴侣。二。在温和的镍（0）下N-磺酰基脱保护催化了Kumada-Corriu-Tamao偶联条件和N-Ans保护基的发展。三， 3,3'-二-（2-吡啶基）-1,1'-bi-2-萘酚配体的合成及应用
6. The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 35-substituted hydantoins [O] . Katarzyna Kucwaj-Brysz, Rafał Kurczab, Ewa Żesławska, 2018

机译：芳基拓扑在平衡35-取代乙内酰脲的选择性和双重5-HT7R / 5-HT1A作用之间的作用
7. Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents [O] . Andreou, Nicolaos-Panagiotis, Dafnopoulos, Konstantinos, Tortopidis, Christos, 2016

机译：烷基和芳基磺酰基对吡啶乙酮肟是有效的DNa光裂解剂
8. The Synthesis of Nitrogen Mustard Derivatives of Hydantoins and Related Compounds as Potential Anti-Brain Tumor Agents. [R] . gerhard,harry john 1977

机译：作为潜在抗脑肿瘤药物的乙内酰脲和相关化合物的氮芥衍生物的合成。

Chiral aryl sulfonyl hydantoins as hypoglycemic agents

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