Sila-substitution of the alpha-amino acid proline: Synthesis of rac- and (R)-4,4-dimethyl-4-sila-proline ethyl ester

Handmann VI.; Tacke R.; Merget M.

首页> 外文期刊>Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences >Sila-substitution of the alpha-amino acid proline: Synthesis of rac- and (R)-4,4-dimethyl-4-sila-proline ethyl ester

【24h】

Sila-substitution of the alpha-amino acid proline: Synthesis of rac- and (R)-4,4-dimethyl-4-sila-proline ethyl ester

机译：α-氨基酸脯氨酸的Sila取代：rac-和（R）-4,4-二甲基-4-sila-脯氨酸乙酯的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In context with studies on silicon-containing alpha-amino acids and peptides, a strategy for the synthesis of the 4-sila-proline skeleton was developed. The synthesis of rac- and (R)-4,4dimethyl-4-sila-proline ethyl ester [rac-2 and (R)-2] is described. Compounds rac-2 and (R)-2 (greater than or equal to 99% ee) were prepared by two-step syntheses, starting from 3,6-diethoxy-2,5-dihydropyrazine and (R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine respectively. [References: 19]

机译：在关于含硅的α-氨基酸和肽的研究的背景下，开发了合成4-sila-脯氨酸骨架的策略。描述了rac-和（R）-4,4-二甲基-4-sila-脯氨酸乙酯[rac-2和（R）-2]的合成。化合物rac-2和（R）-2（大于或等于99％ee）通过两步合成法制备，从3,6-二乙氧基-2,5-二氢吡嗪和（R）-3,6-开始二乙氧基-2-异丙基-2,5-二氢吡嗪。 [参考：19]

著录项

来源
《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |2000年第2期|共6页
作者
Handmann VI.; Tacke R.; Merget M.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
4-sila-proline skeleton; 4; 4-dimethyl-4-sila-proline ethyl ester; Alpha-amino acids; Asymmetric synthesis; Bioorganosilicon chemistry; Asymmetric-synthesis; Enantioselective synthesis;

机译：4-sila-脯氨酸骨架;4;4-二甲基-4-sila-脯氨酸乙酯;α-氨基酸;不对称合成;生物有机硅化学;不对称合成;对映选择性合成;

相似文献

外文文献
中文文献
专利

1. Sila-substitution of the alpha-amino acid proline: Synthesis of rac- and (R)-4,4-dimethyl-4-sila-proline ethyl ester [J] . Handmann VI., Tacke R., Merget M. Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 2000,第2期

机译：α-氨基酸脯氨酸的Sila取代：rac-和（R）-4,4-二甲基-4-sila-脯氨酸乙酯的合成
2. Dehydrogenative Cross-Coupling Reaction between N-Aryl alpha-Amino Acid Esters and Phenols or Phenol Derivative for Synthesis of alpha-Aryl alpha-Amino Acid Esters [J] . Salman Muhammad, Zhu Zhi-Qiang, Huang Zhi-Zhen Organic letters . 2016,第7期

机译：N-芳基α-氨基酸酯与苯酚或苯酚衍生物合成α-芳基α-氨基酸酯的脱氢交叉偶联反应
3. Dehydrogenative Cross-Coupling Reaction between N-Aryl alpha-Amino Acid Esters and Phenols or Phenol Derivative for Synthesis of alpha-Aryl alpha-Amino Acid Esters [J] . Salman Muhammad, Zhu Zhi-Qiang, Huang Zhi-Zhen Organic letters . 2016,第7期

机译：N-芳基α-氨基酸酯与苯酚或苯酚衍生物合成α-芳基α-氨基酸酯的脱氢交叉偶联反应
4. Synthesis of (R)-(-)-mandelic acid ethyl ester by asymmetric reduction of ethyl benzoylformate with yeast cells [C] . OU Zhimin, NAN Yingkang MST-S 2012 . 2012

机译：通过酵母细胞的不对称还原（R） - （ - ） - （ - ） - 蛋白酸乙酯的合成
5. I. Synthesis of alpha-amino acid esters. Dynamic kinetic resolution of zirconaaziridines with an optically active carbon dioxide synthon. II. Mechanism of alpha-amino amidine formation from zirconaaziridines and carbodiimides. [D] . Tunge, Jon Alan. 2000

机译：I.α-氨基酸酯的合成。氧化锆氮杂环丁烷与旋光二氧化碳合成子的动态动力学拆分。二。由氧化锆氮丙啶和碳二亚胺形成α-氨基am的机理。
6. Combination of ester biosynthesis and ω-oxidation for production of mono-ethyl dicarboxylic acids and di-ethyl esters in a whole-cell biocatalytic setup with Escherichia coli [O] . Youri M. van Nuland, Gerrit Eggink, Ruud A. Weusthuis 2017

机译：酯生物合成和ω-氧化的组合用于在大肠杆菌的全细胞生物催化装置中生产单乙基二羧酸和二乙基酯
7. The reactions of alpha-amino acids and alpha-amino acid esters with high valent transition metal halides: synthesis of coordination complexes, activation processes and stabilization of alpha-ammonium acylchloride cations [O] . Biancalana, L., Bortoluzzi, M., Ferretti, E., 2017

机译：α-氨基酸和α-氨基酸酯与高价过渡金属卤化物的反应：配位化合物的合成，活化过程和α-铵氯酰阳离子的稳定化

Sila-substitution of the alpha-amino acid proline: Synthesis of rac- and (R)-4,4-dimethyl-4-sila-proline ethyl ester

摘要

著录项

相似文献

相关主题

期刊订阅