An efficient and simple route to prospective biologically active isoindoloquinazoline, pyrimidine and thiazine derivatives using 2-amino-N'-arylbenzamidine and related compounds as starting materials

Abdel-Latif F.F.; El-Shaieb K.M.; El-Deen A.G.

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An efficient and simple route to prospective biologically active isoindoloquinazoline, pyrimidine and thiazine derivatives using 2-amino-N'-arylbenzamidine and related compounds as starting materials

机译：以2-氨基-N'-芳基苯甲m及相关化合物为起始原料的前瞻性生物活性异吲哚并喹唑啉，嘧啶和噻嗪衍生物的高效简便方法

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The reaction of (Z)-2-amino-N'-arylbenzamidines 1, 2-amino-4,5,6,7- tetrahydrobenzo[b]-thiophene-3-carboxamide (4) and 4-amino-5-substituted-2- (phenylamino)thiophene-3-carboxamides 12 with o-phthalaldehyde (2), terephthalaldehyde (9), and 4-formyl[2.2]paracyclophane (16) in ethanol under reflux conditions afforded isoindoloquinazoline, thienopyrimidine, pyrimidine and thiazine derivatives, respectively. The products were characterized based on their spectroscopic data and elemental analysis.

机译：（Z）-2-氨基-N'-芳基苯甲m 1、2-氨基-4,5,6,7-四氢苯并[b]-噻吩-3-甲酰胺（4）和4-氨基-5-取代的反应在乙醇中，在回流条件下，将-2-（苯基氨基）噻吩-3-甲酰胺12与邻苯二甲醛（2），对苯甲醛（9）和4-甲酰基[2.2]对环环烷（16）在乙醇中提供异吲哚并喹唑啉，噻吩并嘧啶，嘧啶和噻嗪衍生物，分别。根据产品的光谱数据和元素分析对产品进行表征。

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来源
《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |2011年第9期|共7页
作者
Abdel-Latif F.F.; El-Shaieb K.M.; El-Deen A.G.;
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正文语种 eng
中图分类化学;
关键词
Aldehydes; Amidines; Quinazolines; Thiazines; Thienopyrimidines;

机译：醛;A;喹唑啉;噻嗪;硫代嘧啶;

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1. An efficient and simple route to prospective biologically active isoindoloquinazoline, pyrimidine and thiazine derivatives using 2-amino-N'-arylbenzamidine and related compounds as starting materials [J] . Abdel-Latif F.F., El-Shaieb K.M., El-Deen A.G. Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 2011,第9期

机译：以2-氨基-N'-芳基苯甲m及相关化合物为起始原料的前瞻性生物活性异吲哚并喹唑啉，嘧啶和噻嗪衍生物的高效简便方法
2. Development of new fungicides against Magnaporthe grisea: Synthesis and biological activity of pyrazolo[3,4-d][1,3]thiazine, pyrazolo[1,5-c][1,3,5]thiadiazine and pyrazolo[3,4-d]pyrimidine derivatives [J] . Vicentini CB, Forlani G, Manfrini M, Journal of Agricultural and Food Chemistry . 2002,第17期

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3. Zn[(L)proline]₂: An Efficient Catalyst for the Synthesis of Biologically Active Pyrano[2,3-d]pyrimidine Derivatives [J] . Synthetic Communications . 2010,第13期

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4. SYNTHESIS OF HETEROCICLIC COMPOUNDS USING SUGAR DERIVATIVES AS STARTING MATERIAL [C] . Tana L.Canda, Albertina B. Canda, Vanel J. Bessa International Carbohydrate Symposium . 2018

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5. Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression [O] . Andrijana Meščić, Thomas Betzel, Adrienne Müller, 2013

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An efficient and simple route to prospective biologically active isoindoloquinazoline, pyrimidine and thiazine derivatives using 2-amino-N'-arylbenzamidine and related compounds as starting materials

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