Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities

El-Sayed Naglaa F.; Ewies Ewies F.; El-Hussieny Marwa; Boulos Leila S.; Shalaby ElSayed M.

首页> 外文期刊>Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences >Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities

【24h】

Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities

机译：使用有机磷，锑，砷化氢试剂合成新型吡唑衍生物及其抗肿瘤活性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphanes, triphenylstibane, triphenylarsane, and Lawesson's reagent are reported. Structural reasoning for the new products was based on compatible analytical and spectral data. The cytotoxic activity of most of the new products was evaluated against human breast carcinoma cell line (MCF7) and human hepatocellular carcinoma cell line(HepG2). Certain tested compounds showed promising results.

机译：5-叠氮基-3-甲基-1-苯基-1H-吡唑-4-甲醛（叠氮基吡唑）与几种有机磷试剂的反应：磷鎓叶立德，维蒂希-霍纳试剂，二烷基膦酸酯，三烷基亚磷酸酯，三（二烷基氨基）膦，据报道有三苯乙b，三苯ar和劳森试剂。新产品的结构推理基于兼容的分析和光谱数据。评估了大多数新产品对人乳腺癌细胞系（MCF7）和人肝癌细胞系（HepG2）的细胞毒活性。某些测试的化合物显示出令人鼓舞的结果。

著录项

来源
《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |2016年第7期|共12页
作者
El-Sayed Naglaa F.; Ewies Ewies F.; El-Hussieny Marwa; Boulos Leila S.; Shalaby ElSayed M.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
antitumor; azidopyrazole; crystal structure; organophosphorus; stibine;

机译：抗肿瘤;叠氮吡唑;晶体结构;有机磷;二苯乙烯;

相似文献

外文文献
中文文献
专利

1. Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities [J] . El-Sayed Naglaa F., Ewies Ewies F., El-Hussieny Marwa, Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 2016,第7期

机译：使用有机磷，锑，砷化氢试剂合成新型吡唑衍生物及其抗肿瘤活性
2. Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes [J] . Naito H, Ohsuki S, Atsumi R, Chemical and Pharmaceutical Bulletin . 2005,第2期

机译：新型嘧啶基吡唑衍生物的合成及抗肿瘤活性。三， 3-苯基哌嗪基-1-反式丙烯的合成及抗肿瘤活性
3. Site-selective carbonyl substitution in the mixed-metal cluster anion [H_2Ru_3Ir(CO)_(12)]~-: synthesis and characterization of phosphine, phosphite, arsine and stibine derivatives [J] . Georg Suss-Fink, Susanne Haak, Vincent Ferrand, Journal of Organometallic Chemistry . 1999,第2期

机译：混合金属簇阴离子[H_2Ru_3Ir（CO）_（12）]〜-中的位点选择性羰基取代：膦，亚磷酸酯，a和锑的衍生物的合成与表征
4. Synthesis, Characterization and Antitumor Activity of 4-Ferrocenylpyridine-3, 5-Dicarbonitrile Derivatives and Sodium Polymeric Complexes Containing Carbanionic Ligands [C] . E. Klimova, J. Sanchez, M. Flores Materials Research Society symposium . 2015

机译：4-二铁烯基吡啶-3，5-二羰基腈衍生物和含有碳酸碳配体的钠聚合物络合物的合成，表征和抗肿瘤活性
5. Synthesis and derivative chemistry of 2-phosphabutadienes and the reactivity of a two-coordinate phosphine with organolithium reagents. [D] . Jiang, Xiou-Yan. 1999

机译：2-磷丁二烯的合成和衍生物化学以及二配位膦与有机锂试剂的反应性。
6. Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate [O] . Jialong Sun, Yuanming Zhou 2015

机译：新型吡唑羧酰胺和异恶唑醇吡唑羧酸酯的衍生物的合成及抗真菌活性
7. Reactions of Fullerenes with Reactive Methylene Organophosphorus Reagents: Efficient Synthesis of Organophosphorus Group Substituted C60 and C70 Derivatives [O] . -1

机译：富勒烯与反应性甲基有机磷试剂的反应：有效合成有机磷基团取代的C60和C70衍生物

Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities

摘要

著录项

相似文献

相关主题

期刊订阅