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首页> 外文期刊>Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences >Zahramycins A-B, two new steroids from the coral Sarcophyton trocheliophorum
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Zahramycins A-B, two new steroids from the coral Sarcophyton trocheliophorum

机译：Zahramycins A-B，来自珊瑚Sarcophyton trocheliophorum的两种新类固醇

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摘要

Two new poly-hydroxy steroids, zahramycins A (1) and B (2), have been isolated from the polar fraction of the extract of the coral Sarcophyton trocheliophorum. Compound 1 was confirmed to bear an oxirane ring at C-5 and C-6, while 2 has a keto-hydroxy sterol structure. The known DNA primary metabolites uracil, thymine, adenine, uridine, 2'-deoxyuridine, and thymidine were also isolated and identified. Structures of the new sterols 1 and 2 were confirmed by NMR (H, C, 1H-1hcosy, HMQC, HMBC, and NOESY) spectroscopy, mass spectrometry (EI, ESI, and HRMS), and by comparison with related structures. The antimicrobial and cytotoxic activities of compounds 1 and 2 along with that of the coral extract were also determined. Zahramycin B (2) showed high (15 mm) and moderate (12 mm) antibacterial activity against Staphylococcus aureus and Bacillus subtilis, and fungus Pythium ultimum (12mm), while zahramycin A (1) and the crude extract of Sarcophyton trocheliophorum were inactive. Both steroids and the crude extract of Sarcophyton trocheliophorum showed no cytotoxicity.
机译：从珊瑚Sarcophyton trocheliophorum提取物的极性部分中分离出了两种新的多羟基类固醇，扎拉霉素A（1）和B（2）。确认化合物1在C-5和C-6带有环氧乙烷环，而化合物2具有酮-羟基固醇结构。还分离并鉴定了已知的DNA主要代谢产物尿嘧啶，胸腺嘧啶，腺嘌呤，尿苷，2'-脱氧尿苷和胸苷。通过NMR（H，C，1H-1hcosy，HMQC，HMBC和NOESY）光谱，质谱（EI，ESI和HRMS）并与相关结构进行比较来确认新固醇1和2的结构。还确定了化合物1和2以及珊瑚提取物的抗微生物和细胞毒性活性。 Zahramycin B（2）对金黄色葡萄球菌，枯草芽孢杆菌和终极腐霉菌（12mm）具有高（15 mm）和中等（12 mm）的抗菌活性，而Zahramycin A（1）和Sarcophyton trocheliophorum的粗提物则没有活性。类固醇和Srocophyton trocheliophorum的粗提物均无细胞毒性。

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