Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine

Rendi-Wagner P; Shouval D; Genton B; Lurie Y; Rumke H; Boland G; Cerny A; Heim M; Bach D; Schroeder M; Kollaritsch H

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Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine

机译：PreS / S乙型肝炎疫苗在对常规疫苗的非应答和低应答者中的比较免疫原性

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Conventional hepatitis B vaccines do not elicit adequate antibody production in 5-10% vaccinees. This trial tests the ability of a third-generation vaccine, containing PreS1 and PreS2 antigens in addition to the S antigen, to elicit seroprotective titres in documented non- and low-responders, compared with those to a conventional vaccine. In the primary population of non-responders (<10IU/l anti-HBs antibodies after >/=4 previous injections of conventional vaccine) an enhanced antibody response was seen to additional injections of the third-generation vaccine compared with a conventional vaccine (absolute difference 14.9%; P=0.006). Enhanced antibody responses were also found in a population that included low responders.

机译：常规的乙型肝炎疫苗不能在5-10％的疫苗中产生足够的抗体。与传统疫苗相比，该试验测试了除S抗原外还包含PreS1和PreS2抗原的第三代疫苗引起已记录的无反应者和低反应者血清保护性滴度的能力。在无反应的主要人群中（先前注射常规疫苗> / = 4后，<10IU / l抗-HBs抗体），与常规疫苗相比，第三代疫苗的补充注射抗体反应增强（绝对差异14.9％; P = 0.006）。在包括低应答者的人群中也发现了增强的抗体应答。

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《Vaccine》 |2006年第15期|共9页
作者
Rendi-Wagner P; Shouval D; Genton B; Lurie Y; Rumke H; Boland G; Cerny A; Heim M; Bach D; Schroeder M; Kollaritsch H;
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中图分类卫生标准、卫生检查、医药管理;
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1. Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine [J] . Rendi-Wagner P, Shouval D, Genton B, Vaccine . 2006,第15期

机译：PreS / S乙型肝炎疫苗在对常规疫苗的非应答和低应答者中的比较免疫原性
2. Revaccination of non- and low-responders after a standard three dose hepatitis B vaccine schedule [J] . Ke Han, Xiaoping Shao, Huizhen Zheng, Human vaccines . 2012,第12期

机译：标准三剂乙肝疫苗接种计划后无反应者和低反应者再次接种
3. Revaccination of non- and low- responders after a standard three dose hepatitis B vaccine schedule [J] . HanK., ShaoX., ZhengH., Human vaccines & immunotherapeutics. . 2012,第12期

机译：标准三剂乙肝疫苗接种计划后无反应者和低反应者再次接种
4. PRE-CLINICAL AND CLINICAL INVESTIGATION OF THE SAFETY AND IMMUNOGENICITY OF A NOVEL INTRANASAL INFLUENZA VACCINE [C] . R. Glueck International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

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5. Assessment of the immunogenicity of porcine Circovirus 2 (PCV2)vaccines: A prototype vaccine and a lambda display vaccine. [D] . Gamage, Lakshman N. A. 2010

机译：猪圆环病毒2（PCV2）疫苗的免疫原性评估：原型疫苗和λ展示疫苗。
6. Revaccination of non- and low- responders after a standard three dose hepatitis B vaccine schedule [O] . Ke Han, Xiaoping Shao, Huizhen Zheng, 2012

机译：在标准三剂乙型肝炎疫苗接种计划后对无反应者和低反应者进行重新接种
7. Immunogenicity of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine compared to standard-dose diphtheria, tetanus, acellular pertussis when used as a pre-school booster in UK children: A 5-year follow-up of a randomised controlled study. [O] . John, T, Voysey, M, Yu, LM, 2015

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Comparative immunogenicity of a PreS/S hepatitis B vaccine in non- and low responders to conventional vaccine

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