...
首页> 外文期刊>Vaccine >A new highly effective anticysticercosis vaccine expressed in transgenic papaya
【24h】

A new highly effective anticysticercosis vaccine expressed in transgenic papaya

机译:在转基因木瓜中表达的新型高效抗囊虫病疫苗

获取原文
获取原文并翻译 | 示例
           

摘要

The use of transgenic plants as new antigen-delivery systems for subunit vaccines has been increasingly explored. We herein report progress toward a papaya-based vaccine against cysticercosis. Synthetic peptides (KETc1, KETc12, KETc7) were successfully expressed in 19 different transgenic papaya clones and found to be immunogenic. Complete protection against cysticercosis was induced with the soluble extract of the clones that expressed the higher levels of transcripts in up to 90% of the immunized mice. This study represents a key step towards the development of a more effective, sustainable and affordable oral subunit vaccine against human and pig cysticercosis.
机译:越来越多地探索了将转基因植物用作亚单位疫苗的新抗原递送系统的用途。我们在这里报告了针对木瓜病的囊尾rc病疫苗的进展。合成肽(KETc1,KETc12,KETc7)已在19个不同的转基因木瓜克隆中成功表达,并具有免疫原性。克隆的可溶性提取物诱导了针对囊尾rc病的完全保护,所述克隆的可溶性提取物在多达90%的免疫小鼠中表达更高水平的转录本。这项研究是开发针对人类和猪囊尾rc病的更有效,可持续和负担得起的口服亚单位疫苗的关键一步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号