Female genital tract immunization: Evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation

Cremel M; Hamzeh-Cognasse H; Genin C; Delezay O

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Female genital tract immunization: Evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation

机译：女性生殖道免疫：候选免疫佐剂对CCL20上皮细胞分泌和树突状/朗格汉斯细胞成熟的评估

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The female genital tract is an important site for numerous pathogens entry. Local immunization, generating specific mucosal IgA and systemic IgG, represents an interesting alternative immunization pathway. However, such a vaccine strategy needs mucosal adjuvants to obtain the best immune response. Considering that the immunization process is mainly dependent on the capture and on the transport of the antigen by Langerhans cells, we evaluated potential adjuvant molecules by analysing their effects on the CCL20 secretion by endocervical and exocervical/vaginal epithelial cells as well as on dendritic cell and Langerhans cell maturation. We demonstrated that DC-Chol and Zymosan are the most efficient mucosal candidate immunoadjuvants that generate a strong increase of CCL20 secretion by the two epithelial cell lines and the maturation of dendritic and Langerhans cells, respectively.

机译：女性生殖道是许多病原体进入的重要场所。产生特异性粘膜IgA和全身性IgG的局部免疫代表了一种有趣的替代免疫途径。但是，这种疫苗策略需要粘膜佐剂才能获得最佳的免疫反应。考虑到免疫过程主要取决于朗格汉斯细胞对抗原的捕获和转运，我们通过分析其对宫颈内和宫颈外/阴道/上皮细胞以及树突状细胞和CCL20分泌的影响来评估潜在的佐剂分子。朗格汉斯细胞成熟。我们证明DC-Chol和酵母聚糖是最有效的粘膜候选免疫佐剂，可通过两种上皮细胞系以及树突状细胞和朗格汉斯细胞的成熟而强烈增加CCL20的分泌。

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《Vaccine》 |2006年第30期|共11页
作者
Cremel M; Hamzeh-Cognasse H; Genin C; Delezay O;
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中图分类卫生标准、卫生检查、医药管理;
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1. Female genital tract immunization: Evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation [J] . Cremel M, Hamzeh-Cognasse H, Genin C, Vaccine . 2006,第29a30期

机译：女性生殖道免疫：候选免疫佐剂对CCL20上皮细胞分泌和树突状/朗格汉斯细胞成熟的评估
2. Female genital tract immunization: Evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation [J] . Cremel M, Hamzeh-Cognasse H, Genin C, Vaccine . 2006,第29a30期

机译：女性生殖道免疫：候选免疫佐剂对CCL20上皮细胞分泌和树突状/朗格汉斯细胞成熟的评估
3. High-risk human papilloma virus infection decreases the frequency of dendritic Langerhans' cells in the human female genital tract. [J] . Jimenez Flores R, Mendez Cruz R, Ojeda Ortiz J, Immunology: An Official Journal of the British Society for Immunology . 2006,第2期

机译：高危人类乳头瘤病毒感染会降低人类女性生殖道中树突状朗格汉斯细胞的频率。
4. IMMUNIZATION OF DENDRITIC CELLS PULSED WITH PRRS VIRUS GP5 PROTEIN INDUCES CD4+ BUT NOT CD8+ T CELLS [C] . Nguyen-Dinh Quat, Jeongran Min, Jiwon Han, Congress ofthe International Pig Veterinary Society . 2008

机译：用PRRS病毒GP5蛋白脉冲树突细胞的免疫诱导CD4 +但不是CD8 + T细胞
5. Modulation of monocyte-derived dendritic cell maturation and function by cigarette smoke condensate in a bronchial epithelial cell co-culture model [D] . Montpetit, Alison J. 2008

机译：支气管上皮细胞共培养模型中香烟烟雾冷凝物对单核细胞衍生树突状细胞成熟和功能的调节
6. High-risk human papilloma virus infection decreases the frequency of dendritic Langerhans cells in the human female genital tract [O] . Rafael Jimenez-Flores, Rene Mendez-Cruz, Jorge Ojeda-Ortiz, 2006

机译：高危人乳头瘤病毒感染会降低人类女性生殖道中树突状朗格汉斯细胞的频率
7. High-risk human papilloma virus infection decreases the frequency of dendritic Langerhans' cells in the human female genital tract [O] . Jimenez-Flores, Rafael, Mendez-Cruz, Rene, Ojeda-Ortiz, Jorge, 2006

机译：高危人乳头瘤病毒感染会降低人类女性生殖道中树突状朗格汉斯细胞的频率

Female genital tract immunization: Evaluation of candidate immunoadjuvants on epithelial cell secretion of CCL20 and dendritic/Langerhans cell maturation

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