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Experiences with new generation vaccines against equine viral arteritis, West Nile disease and African horse sickness

机译：对抗马病毒性动脉炎，西尼罗河病和非洲马病的新一代疫苗的经验

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Viral diseases constitute an ever growing threat to the horse industry worldwide because of the rapid movement of large numbers of horses for competition and breeding. A number of different types of vaccines are available for protective immunization of horses against viral diseases. Traditional inactivated and live-attenuated (modified live virus, MLV) virus vaccines remain popular and efficacious but recombinant vaccines are increasingly being developed and used, in part because of the perceived deficiencies of some existing products. New generation vaccines include MLVs with deletions and/or mutations of critical genes, subunit vaccines that incorporate immunogenic proteins (or portions thereof) or expression vectors that produce these proteins as immunogens, and DNA vaccines. New generation vaccines have been developed for several viral diseases of horses. We recently have developed an alphavirus replicon-vectored equine arteritis virus (EAV) vaccine, and evaluated a commercial canary pox virus-vectored vaccine for West Nile disease. The success of these new-generation vaccines has catalyzed efforts to develop improved vaccines for the prevention of African horse sickness, a disease of emerging global significance.
机译：由于大量赛马的竞争和繁殖，病毒性疾病对全世界的马业构成了越来越大的威胁。许多不同类型的疫苗可用于对马进行针对病毒性疾病的保护性免疫。传统的灭活和减毒活疫苗（改良的活病毒，MLV）仍然很流行且有效，但是重组疫苗正在越来越多地开发和使用，部分原因是某些现有产品存在缺陷。新一代疫苗包括具有关键基因缺失和/或突变的MLV，掺入免疫原性蛋白质（或其部分）的亚单位疫苗或将这些蛋白质作为免疫原产生的表达载体，以及DNA疫苗。已经开发了用于马的几种病毒性疾病的新一代疫苗。我们最近开发了一种由α病毒复制子载体感染的马动脉炎病毒（EAV）疫苗，并评估了针对西尼罗河病的商业金丝雀痘病毒载体疫苗。这些新一代疫苗的成功催生了开发改进的疫苗以预防非洲马病的努力，这种疾病具有全球重要性。

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