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首页> 外文期刊>Vaccine >Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques
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Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques

机译：猕猴中具有复制能力的V敲除和复制缺陷的F缺失的仙台病毒载体的疫苗的免疫原性评估

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摘要

Viral vectors are promising vaccine tools for eliciting antigen-specific T-cell responses. We previously showed the potential of recombinant Sendai virus (SeV) vectors to induce virus-specific T-cell responses in macaque AIDS models. Here, we have evaluated the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted SeV vectors in macaques. Intranasal replication-competent and replication-defective SeV immunizations both elicited robust systemic antigen-specific T-cell responses, whereas the responses induced by the former were more durable than those by the latter. However, even the latter-induced T-cell responses remained detectable in a local, retropharyngeal lymph node two months after the immunization. These findings are useful for establishment of a vaccine protocol using SeV vectors.
机译：病毒载体是引发抗原特异性T细胞应答的有前途的疫苗工具。我们之前显示了重组仙台病毒（SeV）载体在猕猴AIDS模型中诱导病毒特异性T细胞应答的潜力。在这里，我们评估了猕猴中具有复制能力的V敲除和复制缺陷的F缺失的SeV载体的免疫原性。鼻内复制型和复制缺陷型SeV免疫均引起强健的全身性抗原特异性T细胞应答，而前者诱导的应答比后者诱导的应答更持久。然而，免疫后两个月，即使后者诱导的T细胞应答仍可在局部咽后淋巴结中检测到。这些发现对于使用SeV载体建立疫苗方案是有用的。

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