Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy.

Esposito S; Gasparini C; Martelli A; Zenga A; Tremolati E; Varin E; Marseglia GL; Fiocchi A; Principi N

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Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy.

机译：安全的灭活病毒性佐剂流感疫苗在患有鸡蛋过敏的哮喘儿童中使用。

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In order to evaluate whether the virosomal adjuvanted influenza vaccine that has been shown to have the lowest egg protein content (Inflexal V, Berna Biotech) could be administered to children with even severe egg allergy without any risk of allergic reactions, we used epicutaneous skin testing with the undiluted vaccine in 88 asthmatic children (44 with and 44 without egg allergy), none of whom had a positive response. They were then vaccinated with the whole dose of Inflexal V intramuscularly in a one-dose protocol, and the occurrence of any immediate or delayed adverse events were actively monitored for 28 days. The results showed the safety of the administration, and demonstrated that Inflexal V can be safely given without performing a vaccine skin test in children with any kind of egg allergy.

机译：为了评估是否已证明鸡蛋蛋白含量最低的病毒体辅助流感疫苗（Inflexal V，Berna Biotech）可用于甚至严重鸡蛋过敏的儿童，而没有任何过敏反应的风险，我们使用了表皮皮肤测试88例哮喘儿童（44例有鸡蛋过敏和44例没有鸡蛋过敏）中使用未稀释疫苗接种的儿童，均无阳性反应。然后以一剂方案在肌肉内接种全剂量的Inflexal V疫苗，并在28天之内积极监测任何即时或延迟不良事件的发生。结果显示了给药的安全性，并证明了Inflexal V可以安全地给予任何鸡蛋过敏的儿童而无需进行疫苗皮肤测试。

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《Vaccine》 |2008年第36期|共5页
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Esposito S; Gasparini C; Martelli A; Zenga A; Tremolati E; Varin E; Marseglia GL; Fiocchi A; Principi N;
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中图分类卫生标准、卫生检查、医药管理;
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1. Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy. [J] . Esposito S, Gasparini C, Martelli A, Vaccine . 2008,第36期

机译：安全的灭活病毒性佐剂流感疫苗在患有鸡蛋过敏的哮喘儿童中使用。
2. Immunogenicity and safety of low dose virosomal adjuvanted influenza vaccine administered intradermally compared to intramuscular full dose administration [J] . Kunzi V, Klap JM, Seiberling MK, Vaccine . 2009,第27期

机译：与肌肉内全剂量给药相比，皮内注射低剂量病毒体佐剂型流感疫苗的免疫原性和安全性
3. Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: A PHAC/CIHR Influenza Research Network (PCIRN) study [J] . Langley Joanne M., Scheifele David W., Quach Caroline, Vaccine . 2012,第23期

机译：PHAC / CIHR流感研究网络（PCIRN）研究的2010-2011年含H1N12009的三价灭活流感疫苗在12至59个月大的儿童中曾接受过AS03辅助H1N12009大流行疫苗的安全性和免疫原性
4. N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：N，N，N-三甲基壳聚糖涂覆的整个灭活流感病毒疫苗，用于鼻内给药
5. BECC Adjuvanted Vaccine Provides Broad Protection from Homologous and Heterologous Influenza a Virus Infections [D] . Haupt, Robert. 2021

机译：Becc辅助疫苗提供了来自同源和异源流感的广泛保护病毒感染
6. An open-label randomized clinical trial assessing immunogenicity safety and tolerability of pandemic influenza A/H1N1 MF59-adjuvanted vaccine administered sequentially or simultaneously with seasonal virosomal-adjuvanted influenza vaccine to paediatric kidney transplant recipients [O] . Susanna Esposito, Elisa Meregalli, Cristina Daleno, -1

机译：一项开放标签的随机临床试验对小儿肾脏移植受者依次或同时施用大流行性流感A / H1N1 MF59佐剂大流行性流感疫苗与季节性佐剂性流感疫苗同时进行免疫原性安全性和耐受性
7. Relative Effectiveness of Adjuvanted Trivalent Inactivated Influenza Vaccine Versus Egg-derived Quadrivalent Inactivated Influenza Vaccines and High-dose Trivalent Influenza Vaccine in Preventing Influenza-related Medical Encounters in US Adults ≥ 65 Years During the 2017–2018 and 2018–2019 Influenza Seasons [O] . Constantina Boikos, Lauren Fischer, Dan O’Brien, 2021

机译：佐剂三价灭活流感疫苗的相对有效性与蛋衍生的四轮血液灭活流感疫苗和高剂量三价流感疫苗，在2017-2018和2018-2019流感季节期间预防美国成年人≥65岁的流感相关的医疗障碍
8. Comparison of the Effectiveness of Trivalent Inactivated Influenza Vaccine and Live, Attenuated Influenza Vaccine in Preventing Influenza-Like Illness among US Service Members, 2006-2009. [R] . Phillips, C. J., Woolpert, T., Sevick, C., 2012

机译：2006 - 2009年美国服务成员中三价灭活流感疫苗和活减毒流感疫苗预防流感样疾病的效果比较。

Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy.

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