On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity

Guzzetta G; Manfredi P; Gasparini R; Panatto D; Edmunds WJ

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On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity

机译：脑膜炎球菌传播动力学与疾病之间的关系：体液免疫的评论

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We consider a model for the transmission dynamics of Neisseria meningitidis which incorporates the humoral immunity hypothesis in an explicit way. The "humoral immunity" hypothesis states that individuals will experience significantly different risks of invasive disease depending on whether they are experiencing their first infection episode, or a subsequent one. The model is fitted to the Stonehouse-Danbury carriage data and to UK disease data. For serogroup C (B) the risk of disease during the first infection episode results to be 100 (400) times higher compared to subsequent ones. Moreover the best-fit corresponds to the situation where N. lactamica essentially always confers cross-protection.

机译：我们考虑脑膜炎奈瑟氏球菌的传播动力学模型，该模型以明确的方式结合了体液免疫假说。 “体液免疫”假说指出，个体将经历侵袭性疾病的风险显着不同，这取决于他们是经历第一次感染还是随后感染。该模型适用于Stonehouse-Danbury运输数据和UK疾病数据。对于血清群C（B），与随后的感染相比，首次感染发作期间患病的风险要高100（400）倍。此外，最适合的情况对应于乳酸内杆菌基本上总是提供交叉保护的情况。

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来源
《Vaccine》 |2009年第26期|共6页
作者
Guzzetta G; Manfredi P; Gasparini R; Panatto D; Edmunds WJ;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
Stonehouse-Danbury carriage data; humoral immunity hypothesis;

机译：Stonehouse-Danbury运输数据;体液免疫假说;

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专利

1. On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity [J] . Guzzetta G, Manfredi P, Gasparini R, Vaccine . 2009,第25a26期

机译：脑膜炎球菌传播动力学与疾病之间的关系：体液免疫的评论
2. Humoral immune response to the class 3 outer membrane protein during the course of meningococcal disease. [J] . H K Guttormsen, L M Wetzler, A Naess Infection and immunity . 1993,第11期

机译：脑膜炎球菌疾病过程中对3类外膜蛋白的体液免疫反应。
3. Threshold dynamics of HCV model with cell-to-cell transmission and a non-cytolytic cure in the presence of humoral immunity [J] . Pan Sonjoy, Chakrabarty Siddhartha P. Communications in Nonlinear Science and Numerical Simulation . 2018,第AUGa期

机译：在存在体液免疫的情况下，具有细胞间传播和非溶细胞治疗的HCV模型的阈值动态
4. Effect of Celiac Disease on Humoral Immune Response and Some of the Blood Variables in Children [C] . Qasim Khlaif Abdullah, Ali Abd Sharad, Rajaa Fadhil Hamdi, International Conference on Materials Engineering and Science . 2020

机译：腹腔疾病对儿童体液免疫应答的影响和一些血液变量
5. The Humoral Immune Response to Kaposi's Sarcoma-Associated Herpesvirus and Its Links to Viral Transmission and Pathogenesis [D] . Poppe, Lisa K. 2020

机译：对Kaposi的肉瘤相关的Herpesvirus的体液免疫反应及其与病毒传播和发病机制的联系
6. Humoral immune response to class 1 outer membrane protein during the course of meningococcal disease. [O] . H K Guttormsen, L M Wetzler, C O Solberg 1994

机译：脑膜炎球菌疾病过程中对1类外膜蛋白的体液免疫反应。
7. Mucosal Innate Immune Response Associated with a Timely Humoral Immune Response and Slower Disease Progression after Oral Transmission of Simian Immunodeficiency Virus to Rhesus Macaques▿ [O] . Milush, Jeffrey M., Stefano-Cole, Kelly, Schmidt, Kimberli, 2007

机译：猿猴免疫缺陷病毒经口传播给猕猴后的粘膜固有免疫反应与及时的体液免疫反应和较慢的疾病进展
8. Humoral Immunity in Experimental Syphilis. I. The Demonstration of Resistance Conferred by Passive Immunization. II. The Relationship of Neutralizing Factors in Immune Serum to Acquired Resistance. [R] . Bishop, N. H., Miller, J. N. 1975

机译：实验性梅毒的体液免疫。一，被动免疫引起的抗药性证明。 II。免疫血清中和因子与获得性耐药的关系。

On the relationship between meningococcal transmission dynamics and disease: Remarks on humoral immunity

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