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首页> 外文期刊>Vaccine >Sequence conservation of pilus subunits in Neisseria meningitidis
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Sequence conservation of pilus subunits in Neisseria meningitidis

机译：脑膜炎奈瑟菌中菌毛亚基的序列保守

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The rapid onset and dramatic consequences of Neisseria meningitidis infections make the design of a broadly protective vaccine a priority for public health. There is an ongoing quest for meningococcal components that are surface exposed, widely conserved and can induce protective antibodies. Type IV pili (Tfp) are filamentous structures with a key role in pathogenesis that extend beyond the surface of the bacteria and have demonstrated vaccine potential. However, extensive antigenic variation of PilE, the major subunit of Tfp, means that they are currently considered to be unsuitable vaccine components. Recently it has been shown that Tfp also contain low abundance pilins ComP, PilV and PilX in addition to PilE. This prompted us to examine the prevalence and sequence diversity of these proteins in a panel of N. meningitidis disease isolates. We found that all minor pilins are highly conserved and the major pilin genes are also highly conserved within the ST-8 and ST-11 clonal complexes. These data have important implications for the re-consideration of pilus subunits as vaccine antigens
机译：脑膜炎奈瑟氏球菌感染的快速发作和严重后果使广泛保护性疫苗的设计成为公共卫生的重点。人们正在寻求暴露于表面，广泛保守并能诱导保护性抗体的脑膜炎球菌成分。 IV型菌毛（Tfp）是丝状结构，在发病机理中起关键作用，其作用范围超出细菌的表面，并显示出疫苗的潜力。但是，Tfp的主要亚基PilE的广泛抗原变异意味着它们目前被认为是不合适的疫苗成分。最近显示，Tfp除PilE外还包含低丰度菌毛蛋白ComP，PilV和PilX。这促使我们检查了一组脑膜炎奈瑟氏球菌疾病分离株中这些蛋白的普遍性和序列多样性。我们发现在ST-8和ST-11克隆复合物中，所有次要的菌毛蛋白都是高度保守的，而主要的菌毛蛋白基因也是高度保守的。这些数据对于菌毛亚基作为疫苗抗原的重新考虑具有重要意义。

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