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首页> 外文期刊>Vaccine >Characterization and efficacy determination of commercially available Central American H5N2 avian influenza vaccines for poultry.
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Characterization and efficacy determination of commercially available Central American H5N2 avian influenza vaccines for poultry.

机译：商业化的中美洲家禽H5N2禽流感疫苗的表征和功效测定。

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A poultry vaccination program was implemented in Central America beginning in January 1995 to control both H5N2 low (LPAI) and high pathogenicity avian influenza. This study was conducted to identify seed strain composition and the efficacy of 10 commercially available H5 vaccines against challenge with H5N2 LPAI viruses isolated from Latin America in 2003. The original 1994 vaccine seed virus in commercial inactivated vaccines did not significantly reduce challenge virus shed titers. However, two seed strains of inactivated vaccines, genetically more closely related to the challenge virus, did significantly reduce titers of challenge virus shed from respiratory tract. In addition, a live recombinant fowlpox virus vaccine containing a more distantly related Eurasian lineage H5 gene insert significantly reduced respiratory shedding as compared to sham vaccinates. These results demonstrate the feasibility of identifying vaccine seed strains in commercial finished products for regulatory verification and the need for periodic challenge testing against current field strains in order to select efficacious vaccine seed strains.
机译：1995年1月开始在中美洲实施家禽疫苗接种计划，以控制H5N2低（LPAI）和高致病性禽流感。进行这项研究的目的是确定2003年从拉丁美洲分离出的10种市售H5疫苗对H5N2 LPAI病毒攻击的种子菌株组成和功效。商业灭活疫苗中最初的1994年疫苗种子病毒并未显着降低挑战病毒的棚效价。但是，两种灭活疫苗的种子菌株在基因上与攻击病毒之间的关系更为密切，但确实降低了从呼吸道排出的攻击病毒的滴度。此外，与假疫苗相比，含有更远相关的欧亚血统H5基因插入片段的活重组禽痘病毒疫苗显着降低了呼吸脱落。这些结果证明了在商业成品中鉴定疫苗种子菌株以进行监管验证的可行性，以及针对当前田间菌株进行定期挑战测试以选择有效的疫苗种子菌株的需求。

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