Vaccines in the era of genomics: the pneumococcal challenge

Barocchi MA; Censini S; Rappuoli R

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Vaccines in the era of genomics: the pneumococcal challenge

机译：基因组学时代的疫苗：肺炎球菌的挑战

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In this review we aim to provide the reader with an understanding of the capsular-based complexity of Streptococcus pneumoniae, one of the main limitations to current vaccine development. We then discuss the need for a new vaccine strategy based on proteic antigen candidates discovered in silico. Describing specifically how reverse vaccinology coupled to conventional vaccinology has led to a new paradigm of vaccine development. Finally, we conclude with the importance of defining the pan-genome of the pneumococcus, that is, the sequencing and analysis of multiple genomes from the same species. A critical factor in determining conserved proteins in a group of epidemiologically relevant circulating S. pneumoniae strains, in order to achieve the greatest coverage. Ultimately, the identification of immunogenic surface antigens and assessment of their efficacy will be imperative in the development of a vaccine with the ability to protect against invasive disease independent of serotype.

机译：在这篇综述中，我们旨在为读者提供对肺炎链球菌基于荚膜的复杂性的理解，这是当前疫苗开发的主要局限之一。然后，我们讨论了基于在计算机模拟中发现的蛋白抗原候选物的新疫苗策略的必要性。具体描述反向疫苗学与常规疫苗学的结合如何导致疫苗开发的新范例。最后，我们以定义肺炎球菌的全基因组，即对同一物种的多个基因组进行测序和分析的重要性作为结论。为了确定最大的覆盖范围，在一组流行病学上相关的肺炎链球菌菌株中确定保守蛋白的关键因素。最终，鉴定具有免疫原性的表面抗原并评估其功效对于开发能够抵抗血清型无关的侵袭性疾病的疫苗至关重要。

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《Vaccine》 |2007年第16期|共11页
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Barocchi MA; Censini S; Rappuoli R;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. Vaccines in the era of genomics: the pneumococcal challenge [J] . Barocchi MA, Censini S, Rappuoli R Vaccine . 2007,第16期

机译：基因组学时代的疫苗：肺炎球菌的挑战
2. 13-valent pneumococcal conjugate vaccine immune sera protects against pneumococcal serotype 1,3 and 5 bacteremia in a neonatal rat challenge model [J] . Philip Fernsten, Kathryn W. Mason, Xinhong Yu, Human vaccines . 2011,第Suppla期

机译：13价肺炎球菌结合疫苗免疫血清可预防新生鼠攻击模型中的肺炎球菌血清型1,3和5菌血症
3. Serious complications due to acute rhinosinusitis in children up to five years old in Stockholm, Sweden - Still a challenge in the pneumococcal conjugate vaccine era [J] . Dennison S. Hultman, Ask L. Schollin, Eriksson M., International journal of pediatric otorhinolaryngology . 2019,第期

机译：瑞典斯德哥尔摩年龄急性鼻窦炎的严重并发症是急性鼻窦炎，瑞典仍然是肺炎球菌共轭疫苗时代的挑战
4. Pneumococcal proteins that may constitute the next generation vaccine for pneumococcal disease [C] . David E. Briles, Susan K. Hollingshead, Marilyn J. Crain, International Symposium on Tonsils and Mucosal Barriers of Upper Airways . 2003

机译：肺炎球菌蛋白，可构成肺炎球菌病的下一代疫苗
5. Impact of Pneumococcal Conjugate Vaccine Thirteen Valent on the Reduction of Invasive Pneumococcal Disease. [D] . Coulibaly, Aissata. 2016

机译：肺炎球菌结合疫苗十三价对减少侵袭性肺炎球菌疾病的影响。
6. Operational Challenges in Large Clinical Trials: Examples and Lessons Learned from the Gambia Pneumococcal Vaccine Trial [O] . Felicity T Cutts, Godwin Enwere, Syed M. A Zaman, 2006

机译：大型临床试验中的操作挑战：从冈比亚肺炎球菌疫苗试验中获得的实例和教训
7. Operational Challenges in Large Clinical Trials: Examples and Lessons Learned from the Gambia Pneumococcal Vaccine Trial [O] . Cutts, Felicity T, Enwere, Godwin, Zaman, Syed M. A, 2006

机译：大型临床试验中的操作挑战：从冈比亚肺炎球菌疫苗试验中获得的实例和教训

Vaccines in the era of genomics: the pneumococcal challenge

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