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首页> 外文期刊>Vaccine >Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax
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Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax

机译:炭疽疫苗吸附(AVA)接受者和皮肤及吸入性炭疽患者抗保护性抗原IgG亚类分布的分析

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摘要

The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vaccination with three AVA injections and clinical anthrax elicit anti-PA IgG1, IgG2, and IgG3 subclass responses. An anti-PA IgG4 response was detected in AVA recipients after the fourth injection. The anthrax lethal toxin (LTx) neutralization efficacy of sera from recipients who received 4 to > or =10 AVA injections did not vary significantly in relation to changes in distribution of anti-PA IgG1 and IgG4 subclasses.
机译:在63份疫苗和13例临床炭疽患者的血清横断面研究中确定了对临床炭疽和吸附的不同数量的炭疽疫苗(AVA,BioThrax)注射液的抗PA IgG1,IgG2,IgG3和IgG4亚类反应。数据显示,用3种AVA注射疫苗和临床炭疽疫苗均可引发抗PA IgG1,IgG2和IgG3亚类反应。第四次注射后在AVA受体中检测到抗PA IgG4反应。来自接受4次或大于或等于10次AVA注射的接受者的血清的炭疽致死毒素(LTx)中和功效与抗PA IgG1和IgG4亚类分布的变化无明显差异。

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