Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD

Donofrio G; Sartori C; Franceschi V; Capocefalo A; Cavirani S

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Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD

机译：BoHV-4-载体分泌的嵌合肽BVDV-E2 / BoHV-1-gD的双重免疫策略

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A bovine herpesvirus 4 was isolated from the milk cell fraction of a healthy cow and his full genome cloned as a bacterial artificial chromosome. So cloned viral genome was used as a vector platform to deliver in vitro and in vivo an optimized secreted chimeric peptide obtained by the fusion of the bovine viral diarrhoea virus glycoprotein E2 ectodomain with the bovine herpesvirus 1 glycoprotein D ectodomain. Recombinant virus infected cells robustly expressed and secreted the chimeric peptide into the culture medium and inoculated animals with the recombinant virus successfully responded toward antigens, gE2 and gD. Thus, this work has implications for the development of safe and effective polyvalent vaccines.

机译：从健康母牛的乳细胞部分中分离出牛疱疹病毒4，并将其完整基因组克隆为细菌人工染色体。因此，将克隆的病毒基因组用作载体平台，以在体外和体内递送通过牛病毒性腹泻病毒糖蛋白E2胞外域与牛疱疹病毒1糖蛋白D胞外域融合而获得的优化的分泌型嵌合肽。感染了重组病毒的细胞强烈表达该嵌合肽并将其分泌到培养基中，用重组病毒接种的动物成功地对抗原gE2和gD反应。因此，这项工作对开发安全有效的多价疫苗具有重要意义。

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《Vaccine》 |2008年第48期|共12页
作者
Donofrio G; Sartori C; Franceschi V; Capocefalo A; Cavirani S;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Bacterial artificial chromosomes; Cell culture; Bacterial artificial chromosomes; Cell culture; Diarrhea; Genomes; Immunization; Milk; Vaccines; glycoprotein D; glycoprotein E2; Bovine herpesvirus 1; Bovine herpesvirus 4; Bovine viral diarrhea virus;

机译：细菌人工染色体;细胞培养;细菌人工染色体;细胞培养;腹泻;基因组;免疫;牛奶;疫苗;糖蛋白D;糖蛋白E2;牛疱疹病毒1;牛疱疹病毒4;牛病毒性腹泻病毒;

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1. Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD [J] . Donofrio G, Sartori C, Franceschi V, Vaccine . 2008,第48期

机译：BoHV-4-载体分泌的嵌合肽BVDV-E2 / BoHV-1-gD的双重免疫策略
2. Immunization with a novel chimeric peptide representing B and T cell epitopes from HER2 extracellular domain (HER2 ECD) for breast cancer [J] . Mahdavi Manijeh, Keyhanfar Mehrnaz, Jafarian Abbas, Tumour biology : . 2014,第12期

机译：用代表来自HER2细胞外结构域（HER2 ECD）的B和T细胞表位的新型嵌合肽进行免疫
3. Enhanced humoral and mucosal immune responses after intranasal immunization with chimeric multiple antigen peptide of LcrV antigen epitopes of Yersinia pestis coupled to palmitate in mice. [J] . Uppada S. B., Bhat A. A., Anil Sah, Vaccine . 2011,第50期

机译：鼠疫耶尔森氏菌LcrV抗原表位的嵌合多抗原肽与棕榈酸酯偶联后经鼻内免疫后，增强了体液和粘膜免疫反应。
4. Effect of PCV2 passive antibody levels on immunization with chimeric PCV1-2 vaccine and challenge with wild-type PCV2 [C] . Peter Thomas, Tanja Opriessnig, Nichole McKeown, Annual Meeting of the American Association of Swine Veterinarians . 2005

机译：PCV2无源抗体水平对抗野生型PCV2抗疫苗疫苗免疫的影响
5. Part I. Application of 2-hydroxymethylacrylic acid, a product of Baylis-Hillman reaction, for the synthesis of novel N-backbone-to-side-chain cyclic peptide analogs: Strategies and side reactions. Part II. Synthesis and biological activities of chimeric bioactive peptides featuring amino acids coupled to 4-anilino-n-phenethyl-piperidine. [D] . Petrov, Ravil Rashitovich. 2007

机译：第一部分。Baylis-Hillman反应产物2-羟甲基丙烯酸在合成新型N骨架至侧链环状肽类似物中的应用：策略和副反应。第二部分具有与4-苯胺基-n-苯乙基-哌啶偶联的氨基酸的嵌合生物活性肽的合成和生物活性。
6. Construction and characterization of secreted and chimeric transmembrane forms of Drosophila acetylcholinesterase: a large truncation of the C-terminal signal peptide does not eliminate glycoinositol phospholipid anchoring. [O] . J P Incardona, T L Rosenberry 1996

机译：果蝇乙酰胆碱酯酶的分泌型和嵌合型跨膜形式的构建和表征：C端信号肽的大截断不能消除糖醇糖脂的锚定。
7. Reduction of Respiratory Syncytial Virus Titer in the Lungs of Mice after Intranasal Immunization with a Chimeric Peptide Consisting of a Single CTL Epitope Linked to a Fusion Peptide [O] . Hsu Shiou-Chih, Chargelegue Daniel, Steward Michael W. 1998

机译：鼻内免疫后的小鼠肺中呼吸道合胞病毒滴度的降低，其中嵌合肽由连接融合肽的单个CTL表位组成
8. Peptides and DNA Encoding the Peptides Useful for Immunizations Against Coccidioides spp. Infections. [R] . Galgiani, J. N., Orsborn, K., Peng, T., 2006

机译：编码肽的肽和DNa可用于针对球孢子虫的免疫接种。感染。

Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD

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