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首页> 外文期刊>Vaccine >Measles seroepidemiology and decay rate of vaccine-induced measles IgGtiters in Taiwan, 1995-1997
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Measles seroepidemiology and decay rate of vaccine-induced measles IgGtiters in Taiwan, 1995-1997

机译：1995-1997年台湾的麻疹血清流行病学和疫苗诱导的麻疹IgG滴度的衰减率

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Community-based seroepidemiologic studies were conducted to monitor the effectiveness of measles immunization programmes and to estimate the decay rate of vaccine-induced measles IgG titres. Sera collected from a mountain (792 sera), rural (875 sera) and urban (894 sera) populations in 1995-1997 were available. Measles IgG was quantified using a commercial EIA kit. Measles JOG seroprevalence and geometric mean titre (GMT) were calculated by setting the cut-off titre at 50 mIU/ml. The decay rate of measles IgG titres was estimated by assuming that the measles IgG titres, without exposing to wild measles virus, decay exponentially and constantly after 1 year post vaccination. The half-life of measles IgG titres was calculated from the corresponding decay rate. Measles Ig-G seroprevalences in these three populations have reached > 95% in school children (7-18 years old) and > 98% in young adults (19-25 years old) but varied from 87 to 96% in pre-school children (4-6 years old). Two-dose vaccinees, comparing with 1-dose vaccinees, had a significantly higher seroprevalence (98 versus 92%, P < 0.01) and a slightly longer half-life of measles IgG titres (61 versus 27 months, P = 0.08) but the measles IgG GMT in the two groups did not differ significantly (675 versus 618 mIU/ml, P = 0.78).
机译：开展了基于社区的流行病学研究，以监测麻疹免疫计划的有效性，并估计疫苗诱导的麻疹IgG滴度的衰减率。 1995-1997年可从山区（792个）血清，农村（875个）血清和城市（894个）血清中收集血清。麻疹IgG使用市售EIA试剂盒定量。通过将截止滴度设定为50 mIU / ml来计算麻疹JOG血清阳性率和几何平均滴度（GMT）。通过假定在接种疫苗后1年后未暴露于野生麻疹病毒的情况下，麻疹IgG滴度呈指数级且持续衰减，来估算麻疹IgG滴度的衰减率。从相应的衰减率计算出麻疹IgG滴度的半衰期。这三个人群中的麻疹Ig-G血清阳性率在学龄儿童（7-18岁）中达到> 95％，在青年成年人（19-25岁）中> 98％，但学龄前儿童从87％到96％不等（4-6岁）。与一剂疫苗相比，两剂疫苗的血清阳性率显着更高（98比92％，P <0.01），麻疹IgG滴度的半衰期稍长（61比27个月，P = 0.08），但是两组的麻疹IgG GMT差异无统计学意义（675对618 mIU / ml，P = 0.78）。

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