Tumor-derived exosomes: a new source of tumor rejection antigens

Andre F; Scharz NEC; Chaput N; Flament C; Raposo G; Amigorena S

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Tumor-derived exosomes: a new source of tumor rejection antigens

机译：肿瘤来源的外泌体：肿瘤排斥抗原的新来源

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Exosomes are small vesicles released by a broad array of hematopoietic cells. Previous studies showed that exosomes released by antigen loaded dendritic cells induce immune-mediated anti-tumor response in mice. Here, we will describe the biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines.

机译：外来体是由各种各样的造血细胞释放的小囊泡。先前的研究表明，抗原加载的树突状细胞释放的外泌体在小鼠中诱导免疫介导的抗肿瘤反应。在这里，我们将描述肿瘤来源的外泌体的生化特性及其作为癌症疫苗的临床前活性。

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《Vaccine》 |2002年第4期|共4页
作者
Andre F; Scharz NEC; Chaput N; Flament C; Raposo G; Amigorena S;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Tumor-derived exosomes; Tumor rejection antigens; Cancer vaccines; Active specific immunotherapy; Randomized trial; Dendritic cells; Cancer; Maturation; Vesicles;

机译：肿瘤来源的外泌体;肿瘤排斥抗原;癌症疫苗;主动特异性免疫疗法;随机试验;树突状细胞;癌症;成熟;囊泡;

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专利

1. Tumor-derived exosomes: a new source of tumor rejection antigens [J] . Andre F, Scharz NEC, Chaput N, Vaccine . 2002,第Suppla4期

机译：肿瘤来源的外泌体：肿瘤排斥抗原的新来源
2. Engineering of exosome-triggered enzyme-powered DNA motors for highly sensitive fluorescence detection of tumor-derived exosomes [J] . Yu Yanyan, Zhang Wei S., Guo Yuehua, Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices . 2020,第1期

机译：突出的肿瘤诱导酶促DNA电机的工程，用于高敏感的肿瘤衍生外来荧光检测
3. Interleukin-12-anchored exosomes increase cytotoxicity of T lymphocytes by reversing the JAK/STAT pathway impaired by tumor-derived exosomes [J] . ZhangYao, WuXiao-Hou, LuoChun-Li, International journal of molecular medicine . 2010,第5期

机译：白细胞介素12锚定的外泌体通过逆转肿瘤来源的外泌体损害的JAK / STAT途径来增加T淋巴细胞的细胞毒性
4. Tumor-Derived Exosomes-Based Cancer Early Detection: A Molecular Dynamics Simulation [C] . Atiyeh Hosseini, Lida Ghazanfari, Mohammad Mahdi Hasani-Sadrabadi Iranian Conference on Biomedical Engineering . 2015

机译：肿瘤衍生的外泌体基癌症早期检测：分子动力学模拟
5. Exploration of the drug delivery potential of tumor-derived exosomes. [D] . Smyth, Tyson Jerel. 2014

机译：探索肿瘤来源的外泌体的药物递送潜力。
6. Tumor-Derived Exosomes Confer Antigen-Specific Immunosuppression in a Murine Delayed-Type Hypersensitivity Model [O] . Chenjie Yang, Seon-Hee Kim, Nicole R. Bianco, 2008

机译：肿瘤衍生的外来体在小鼠迟发型超敏反应模型中赋予抗原特异性的免疫抑制。
7. Tumor-Derived Exosomes Confer Antigen-Specific Immunosuppression in a Murine Delayed-Type Hypersensitivity Model [O] . Yang Chenjie, Kim Seon-Hee, Bianco Nicole R, 2011

机译：肿瘤衍生的外来体在小鼠迟发型超敏反应模型中赋予抗原特异性的免疫抑制。

Tumor-derived exosomes: a new source of tumor rejection antigens

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