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首页> 外文期刊>Vaccine >Reduced detection and levels of protective antibodies to hepatitis B vaccine in under 2-year-old HIV positive South African children at a paediatric outpatient clinic
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Reduced detection and levels of protective antibodies to hepatitis B vaccine in under 2-year-old HIV positive South African children at a paediatric outpatient clinic

机译：在儿科门诊中降低2岁以下HIV阳性南非儿童中乙型肝炎疫苗的检测率和保护性抗体水平

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The study evaluated and compared the prevalence of anti-HBs and exposure to hepatitis B virus (HBV) in vaccinated South African babies aged between 5 and 24 months from the Expanded Programme on Immunisation clinic [EPI group] and paediatric outpatient clinic [OPD group], and results were stratified by HIV status. A total of 303 (243 EPI group and 60 OPD group) babies were studied. All sera were tested for anti-HBs, HBsAg and anti-HBc, while IgM anti-HBc and HBV DNA were only tested in samples positive for HBsAg and/or anti-HBc. Overall, there was a gross difference in the prevalence of anti-HBs marker between the EPI and OPD groups. The EPI group demonstrated higher levels of seroconversion (89.3% vs. 81.7%; p=0.105) and seroprotection rates (86.0% vs. 75.0%; p=0.038), compared to the OPD babies. When the overall results were stratified by HIV status, seroprotection was 85.7% for the HIV-negatives and 78.1% for the HIV-positives, although this was not statistically significant (p=0.125). The seroprotection rates were almost comparable between the HIV-positives (84.3%; n=51) and the HIV-negatives (86.5%; n=192) (p=0.695) in the EPI group. In contrast, reduced seroprotection rates were observed between the HIV-positives (63.6%; n=22) and HIV-negatives (81.6%; n=38) in the OPD group, although this was not statistically significant (p=0.123). Interestingly, no HBsAg or anti-HBc marker was detected in the OPD group, compared to total exposure rate of 4.9% (HBsAg carriage was 1.2%) in the EPI group.
机译：该研究评估并比较了扩大免疫规划[EPI组]和儿科门诊[OPD组]的5至24个月免疫接种的南非婴儿中抗HBs的患病率和暴露于乙型肝炎病毒（HBV）的情况。 ，结果按HIV状况分层。共研究了303名婴儿（243名EPI组和60名OPD组）。所有血清均进行了抗-HBs，HBsAg和抗-HBc检测，而IgM抗-HBc和HBV DNA仅在HBsAg和/或抗-HBc阳性样品中进行了检测。总体而言，EPI和OPD组之间抗HBs标志物的患病率存在​​明显差异。与OPD婴儿相比，EPI组的血清转化率更高（89.3％比81.7％; p = 0.105）和血清保护率（86.0％比75.0％; p = 0.038）。如果按HIV状况对总体结果进行分层，则HIV阴性患者的血清保护率为85.7％，HIV阳性患者的血清保护率为78.1％，尽管这在统计学上没有统计学意义（p = 0.125）。在EPI组中，HIV阳性（84.3％; n = 51）和HIV阴性（86.5％; n = 192）之间的血清保护率几乎相当。相反，在OPD组中，观察到HIV阳性（63.6％; n = 22）和HIV阴性（81.6％; n = 38）之间的血清保护率降低，尽管这在统计学上并不显着（p = 0.123）。有趣的是，OPD组中未检测到HBsAg或抗HBc标记物，而EPI组中的总暴露率为4.9％（HBsAg携带率为1.2％）。

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