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首页> 外文期刊>Vaccine >Effect of sequence variation in meningococcal PorA outer membrane proteinon the effectiveness of a hexavalent PorA outer membrane vesicle vaccine
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Effect of sequence variation in meningococcal PorA outer membrane proteinon the effectiveness of a hexavalent PorA outer membrane vesicle vaccine

机译：脑膜炎球菌PorA外膜蛋白序列变异对六价PorA外膜囊泡疫苗有效性的影响

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Though meningococcal serogroup C conjugate vaccines have been introduced into the UK infant immunisation schedule, there is currently no vaccine solution for serogroup B disease. PorA outer membrane protein (OMP) is a potential serogroup B vaccine candidate. A hexavalent PorA outer membrane vesicle (OMV) vaccine has been evaluated in phase I and II trials with promising results. This vaccine contains six different PorA OMPs each representing a different serosubtype, However, considerable sequence variation occurs in the variable regions (VRs) encoding these serosubtypes. By using recombinant P1.5,10 PorA variants we have demonstrated that the killing of this particular serosubtype combination was due mainly to the induction of antibody to the VR2 (P1.10) epitope region, and that after three or four doses of vaccine then was a significant reduction in the killing of variants P1.10a (three doses, p < 0.0001; four doses, p = 0.003) and P1.10f (three doses, p < 0.0001: four doses, p = 0.002, as compared to responses to the P1.10 strain, when the P1.10 serosubtype was used as the immunogen. Since large numbers of serosubtype variants are known to exist, this finding may have implications for the use of PorA as a meningococcal serogroup B vaccine.
机译：尽管脑膜炎球菌C血清群结合疫苗已被引入英国婴儿免疫计划，但目前尚无针对B血清群疾病的疫苗解决方案。 PorA外膜蛋白（OMP）是潜在的B血清群疫苗候选者。六价PorA外膜囊泡（OMV）疫苗已在I和II期试验中进行了评估，并获得了可喜的结果。该疫苗包含六个不同的PorA OMP，每个代表不同的血清亚型。但是，在编码这些血清亚型的可变区（VR）中会发生相当大的序列变异。通过使用重组P1.5,10 PorA变体，我们证明了杀死这种特定的血清亚型组合主要是由于诱导了针对VR2（P1.10）表位区域的抗体，然后经过三或四剂疫苗与应答相比，变体P1.10a（三剂，p <0.0001;四剂，p = 0.003）和P1.10f（三剂，p <0.0001：四剂，p = 0.002）的杀伤力显着降低当使用P1.10血清亚型作为免疫原时，对于P1.10菌株，由于已知存在大量的血清亚型变体，这一发现可能对PorA作为脑膜炎球菌B血清群疫苗的使用有影响。

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