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Immunogenicity and reactogenicity of the combined hepatitis A and Bvaccine in young adults

机译：年轻人中甲型肝炎和牛痘疫苗联合的免疫原性和反应原性

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The combination of hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccinations can offer convenience, increased compliance and cost saving. We have studied the immunogenicity, reactogenicity and safety of combined hepatitis A and B vaccination in young adults (16-35 years old). Eighty healthy young adults were divided into two random groups. One group received the combined hepatitis A and B vaccine (HAB) in one arm while the other group was administered concomitant hepatitis A and B vaccines (HAV + HBV) in the right and left arms, respectively. The immunogenicity, reactogenicity and safety were assessed after each dose in both the groups. In local symptoms, the percentage of the combined HAB group was lower than the HAV + HBV group, and the general symptoms were noted in approximately 30% of each group without any significant difference. No serious adverse effects were noted. All the subjects were seropositive for antibody to hepatitis A virus (anti-HAV) after one dose of vaccine, and remained seropositive after three doses in both groups. The seropositive rate for antibody to hepatitis B surface antigen (anti-HBs) was significantly higher (84%) in the combined HAB group than the concomitant HAV + HBV group (62%), (p < 0.05) after dose two, and all the subjects were seropositive (100%) after the third dose. The GMTs of anti-HAV and anti-HBs were not significantly different between groups 1 and 2 (p > 0.1) except in month 6 when the GMT of anti-HBs was higher in HAB group (p = 0.0039). The combined HAB vaccine was found to be safe, well tolerated and had less local symptoms in young adults. The immunogenicity and reactogenicity were similar to the concomitant HAV + HBV vaccines.
机译：甲型肝炎病毒（HAV）和乙型肝炎病毒（HBV）疫苗的组合可以提供方便，增加依从性并节省成本。我们已经研究了年轻人（16-35岁）联合接种甲肝和乙肝疫苗的免疫原性，反应原性和安全性。将80名健康的年轻人分为两组。一组在一只手臂中接受甲肝和乙肝联合疫苗（HAB），而另一组在右臂和左臂中分别接受甲肝和乙肝疫苗（HAV + HBV）。在两组中每次给药后评估其免疫原性，反应原性和安全性。在局部症状方面，合并的HAB组的百分比低于HAV + HBV组，并且在每组中大约30％注意到一般症状，没有任何显着差异。没有发现严重的不良反应。接种一剂疫苗后，所有受试者的甲型肝炎病毒抗体（抗-HAV）均为血清阳性，两组均接种三剂后仍呈血清阳性。联合HAB组中乙型肝炎表面抗原（抗HBs）抗体的血清阳性率（84％）显着高于伴随HAV + HBV组（62％），在第二次给药后（p <0.05）在第三次给药后受试者血清反应阳性（100％）。第1组和第2组之间抗HAV和抗HBs的GMT差异无统计学意义（p> 0.1），而第6个月HAB组中抗HBs的GMT较高（p = 0.0039）。发现混合的HAB疫苗是安全的，耐受性良好的，并且在年轻人中具有较少的局部症状。免疫原性和反应原性与伴随的HAV + HBV疫苗相似。

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