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首页> 外文期刊>Vaccine >Modified live marker vaccine candidate CP7_E2alf provides early onset of protection against lethal challenge infection with classical swine fever virus after both intramuscular and oral immunization.
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Modified live marker vaccine candidate CP7_E2alf provides early onset of protection against lethal challenge infection with classical swine fever virus after both intramuscular and oral immunization.

机译：经修饰的活标记疫苗候选CP7_E2alf可在肌肉和口服免疫后尽早预防经典猪瘟病毒的致死性攻击感染。

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Due to the vast economic consequences of classical swine fever (CSF) outbreaks, emergency vaccination plans are under discussion in European Union Member States. However, animals vaccinated with the conventional C-strain vaccine are subject to trade restrictions. To ease these restrictions, potent marker vaccines are required. One promising candidate is the chimeric pestivirus CP7_E2alf. For emergency vaccination in a CSF outbreak scenario, early onset of immunity is required. Here, the studies performed with a CP7_E2alf virus stock produced under good manufacturing conditions (GMP) are reported. In challenge experiments, CP7_E2alf induced full clinical protection 1 week after intramuscular vaccination, and 2 weeks after oral immunization. Furthermore, even after application of diluted vaccine preparations complete protection could be achieved if challenge infection was carried out 4 weeks after vaccination. In conclusion, GMP-produced CP7_E2alf proved to be a suitable marker vaccine candidate - also for emergency vaccination - both after intramuscular and oral application.
机译：由于经典猪瘟（CSF）爆发的巨大经济后果，欧盟成员国正在讨论紧急疫苗接种计划。但是，接种常规C株疫苗的动物受到贸易限制。为了减轻这些限制，需要有效的标记疫苗。嵌合瘟病毒CP7_E2alf是一种很有前途的候选物。对于CSF爆发情况下的紧急疫苗接种，需要尽早开始免疫。在此，报告了对在良好制造条件（GMP）下生产的CP7_E2alf病毒库进行的研究。在挑战实验中，CP7_E2alf在肌肉注射后1周和口服免疫后2周诱导了全面的临床保护。此外，即使在接种稀释疫苗制剂后，如果在疫苗接种后4周进行挑战感染，也可以实现完全保护。总之，经肌肉注射和口服后，GMP生产的CP7_E2alf被证明是合适的标记疫苗候选对象-也用于紧急疫苗接种。

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