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首页> 外文期刊>Vaccine >Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.
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Amount of maternal rotavirus-specific antibodies influence the outcome of rotavirus vaccination of newborn mice with virus-like particles.

机译:母体轮状病毒特异性抗体的数量会影响用病毒样颗粒对新生小鼠进行轮状病毒疫苗接种的结果。

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摘要

In presence of low or high levels of rotavirus-specific maternal antibodies, the ability of newborn mice to respond to immunization with rotavirus RF 8*-2/6/7 VLPs, was evaluated. After parenteral vaccination, 100% of offspring born to low-antibody-titer dams developed rotavirus-specific IgG antibodies (n=7). In contrast, only 25% of offsprings born to high-antibody-titer dams responded to parenteral immunization (n=12). When comparing parenteral versus oral immunization in offspring to low-antibody-titer dams only 45% responded after oral immunization (n=6). In conclusion, the response to parenteral immunization was not hampered by the presence of low levels of maternal antibodies induced by a natural infection while oral immunization was impaired. However, high levels of maternal antibodies impaired the response to parenteral immunization.
机译:在存在低水平或高水平轮状病毒特异性母源抗体的情况下,评估了新生小鼠对轮状病毒RF 8 * -2 / 6/7 VLP免疫反应的能力。肠胃外疫苗接种后,低抗体滴定水坝出生的后代有100%产生轮状病毒特异性IgG抗体(n = 7)。相比之下,只有25%的高抗体滴定水坝后代对肠胃外免疫产生反应(n = 12)。比较低抗体滴定后代的肠胃外与口服免疫后,口服免疫后只有45%应答(n = 6)。总之,在口服免疫受损的同时,自然感染引起的母源抗体水平低并不会妨碍对肠胃外免疫的反应。但是,高水平的母源抗体会削弱对肠胃外免疫的反应。

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