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首页> 外文期刊>Vaccine >Case-control study of allergic reactions to Japanese encephalitis vaccine.
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Case-control study of allergic reactions to Japanese encephalitis vaccine.

机译：对日本脑炎疫苗过敏反应的病例对照研究。

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A case-control study, including 49 travellers with allergic reactions and 148 travellers without similar reactions after Japanese encephalitis (JE) vaccination between October 1992 and February 1993 at the Statens Serum Institut, Copenhagen, Denmark, was performed to clarify any possible risk factors. About one-third of the adverse reactions of the vaccine could be attributed to an allergic predisposition in the vaccinees. The main risk factors were young age, female gender and previous allergic skin reactions or hayfever. The study also indicated that cases more often reacted to nickel and more often had severe oedema after mosquito or other insect bites. Hormone intake was more often spontaneously reported by females in the case group. It is suggested that information on any history of allergy of young adults should be given before JE vaccination, the vaccination should be carried out more than a week before departure and antihistamine treatment should be available if a reaction occurs.
机译：在1992年10月至1993年2月间，在丹麦哥本哈根的史坦顿血清研究所进行了一项病例对照研究，包括49名有过敏反应的旅行者和148名在日本脑炎（JE）疫苗接种后没有类似反应的旅行者，以阐明任何可能的危险因素。疫苗的不良反应约三分之一可归因于疫苗接种者的过敏性倾向。主要危险因素是年轻，女性和以前的过敏性皮肤反应或花粉热。研究还表明，蚊子或其他昆虫叮咬后，患者对镍的反应更加频繁，并出现严重的水肿。病例组中女性更经常自发报告激素摄入。建议在进行JE疫苗接种之前应提供有关年轻人过敏史的信息，应在出发前一周以上进行疫苗接种，如果发生反应应提供抗组胺药治疗。

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