Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine

Nolan T; Ruff TA; Lambert SB; Buttery J; OGrady KA; Streeton C; Hoet B; Bock HL

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Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine

机译：降低抗原含量的白喉患儿加强接种白喉-破伤风-无细胞百日咳疫苗

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Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18 - 20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and > or = 93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given.

机译：在18至20个月大的DTPa引发的学步儿童中，将DTPa和降低的抗原dTpa加强疫苗的免疫原性和反应原性与甲型肝炎对照疫苗进行了比较。加强免疫后，所有DTPa和dTpa接受者都获得了白喉和破伤风的血清保护，≥93.3％的人对百日咳有增强反应。 DTPa和dTpa疫苗接种者的反应原率相似。几乎没有3级症状的报道。对照组中有超过四分之一的儿童白喉抗体达到或可能低于保护基准的相关系数（0.016IU / ml）。较大的研究应评估在该年龄没有接受DTPa加强剂量的儿童中，减少抗原疫苗和血清保护的潜在益处，包括对白喉的防护，直到随后给予加强剂量。

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《Vaccine》 |2009年第18期|共4页
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Nolan T; Ruff TA; Lambert SB; Buttery J; OGrady KA; Streeton C; Hoet B; Bock HL;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine [J] . Nolan T, Ruff TA, Lambert SB, Vaccine . 2009,第18期

机译：降低抗原含量的白喉患儿加强接种白喉-破伤风-无细胞百日咳疫苗
2. Booster vaccination of pre-school children with reduced-antigen-content diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine co-administered with measles-mumps-rubella-varicella vaccine A randomized, controlled trial in children primed according to a 2 + 1 schedule in infancy [J] . Giuseppe Ferrera, Mario Cuccia, Gabriele Mereu, Human vaccines . 2012,第3期

机译：降低抗原含量的白喉-破伤风-无细胞百日咳灭活的脊髓灰质炎病毒疫苗与麻疹-腮腺炎-风疹-水痘疫苗联合接种的学龄前儿童加强免疫接种根据2 + 1时间表对儿童进行的随机对照试验婴儿期
3. Booster vaccination of pre-school children with reduced-antigen-content diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine co-administered with measles-mumps-rubella-varicella vaccine: A randomized, controlled trial in children primed according to a 2+1 schedule in infancy [J] . FerreraG., CucciaM., MereuG., Human vaccines . 2012,第3期

机译：降低抗原含量的白喉-破伤风-无细胞百日咳灭活的脊髓灰质炎病毒疫苗与麻疹-腮腺炎-风疹-水痘疫苗联合接种对学龄前儿童的加强疫苗接种：一项根据2 + 1引发的儿童随机对照试验婴儿期时间表
4. Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus,Acellular Pertussis, Inactivated Poliovirus,and Haemophilus Influenzae Type b [C] . Yuelian Sun, Jakob Christensen, Anders Hviid, Second joint biostatistics symposium (2012) . 2012

机译：接种白喉，破伤风，无细胞百日咳，脊髓灰质炎灭活病毒和b型流感嗜血杆菌疫苗后出现高热惊厥和癫痫的风险
5. Healthcare Provider and Support Staff Education to Increase Tetanus, Diphtheria, and Acellular Pertussis Immunizations Among Pregnant Women in a Mid-Western Ob/Gyn Clinic [D] . Henderson, Krissi. 2020

机译：医疗保健提供者和支持人员教育增加了患有中西部ob / gyn诊所的孕妇中的破伤风，白喉和患有细胞植物免疫
6. Booster vaccination of pre-school children with reduced-antigen-content diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine co-administered with measles-mumps-rubella-varicella vaccine [O] . Giuseppe Ferrera, Mario Cuccia, Gabriele Mereu, 2012

机译：降低抗原含量的白喉-破伤风-无细胞百日咳灭活的脊髓灰质炎病毒疫苗与麻疹-腮腺炎-风疹-水痘疫苗联合应用对学龄前儿童的加强疫苗接种
7. Immunogenicity and reactogenicity of a decennial booster dose of a combined reduced-antigen-content diphtheria–tetanus–acellular pertussis and inactivated poliovirus booster vaccine (dTpa–IPV) in healthy adults [O] . Kovac Martina, Rathi Niraj, Kuriyakose Sherine, 2015

机译：降低抗原含量的白喉-破伤风-无细胞百日咳组合抗原和灭活脊髓灰质炎加强疫苗（dTpa-IPV）联合使用的十年一次加强剂量的免疫原性和反应原性
8. Preventing Tetanus, Diphtheria, and Pertussis Among Adults: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine: Recommendation of ACIP, Supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), [R] . Kretsinger, K. 2006

机译：在成人中预防破伤风，白喉和百日咳：使用破伤风类毒素，减少白喉类毒素和无细胞百日咳疫苗：aCIp的推荐，由医疗保健感染控制实践咨询委员会（HICpaC）支持，

Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine

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