Francisella tularensis vaccines. (Special Issue: Vaccines for biodefense.)

Oyston P. C. F.

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Francisella tularensis vaccines. (Special Issue: Vaccines for biodefense.)

机译：Francisella tularensis 疫苗。（特刊：生物防御疫苗。）

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Francisella tularensis has attracted attention historically as a biological weapon, due to its high infectivity in aerosols, and the severity of disease in humans. There is no licensed vaccine currently available, although an attenuated live vaccine strain (LVS) was identified in the middle of the last century and has been successfully used to protect humans. Efforts are underway to determine the basis of attenuation of LVS, and to understand the immunity required for protection. Alternative approaches to produce subunit vaccines and defined attenuated strains are also in progress. However, the limitations of animal models may make licensing a candidate vaccine challenging.

机译：历史上，图拉弗朗西斯菌（Francisella tularensis）作为一种生物武器已受到人们的关注，原因是它在气溶胶中的传染性高，并且人类疾病严重。尽管在上个世纪中叶发现了减毒活疫苗株（LVS），并且已成功用于保护人类，但目前没有获得许可的疫苗。正在努力确定LVS衰减的基础，并了解保护所需的抗扰性。生产亚单位疫苗和确定的减毒株的替代方法也在开发中。但是，动物模型的局限性可能会使候选疫苗的许可面临挑战。

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《Vaccine》 |2009年第4期|共4页
作者
Oyston P. C. F.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
human diseases; licences; live vaccines; reviews; tularaemia; vaccine development; Francisella tularensis;

机译：人类疾病;许可证;活疫苗;综述;图莱血症;疫苗开发;图拉弗朗西斯菌;

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1. Francisella tularensis vaccines. (Special Issue: Vaccines for biodefense.) [J] . Oyston P. C. F. Vaccine . 2009,第Suppla4期

机译：Francisella tularensis 疫苗。（特刊：生物防御疫苗。）
2. Influenza vaccines. (Special Issue: Vaccines for biodefense.) [J] . Ellebedy A. H., Webby R. J. Vaccine . 2009,第Suppla4期

机译：流感疫苗。（特刊：生物防御疫苗。）
3. Advances in the development of next-generation anthrax vaccines. (Special Issue: Vaccines for biodefense.) [J] . Friedlander A. M., Little S. F. Vaccine . 2009,第Suppla4期

机译：下一代炭疽疫苗的开发进展。（特刊：生物防御疫苗。）
4. Preparation of Pure O-antigen Containing Saccharides from Francisella tularensis LPS for Vaccine Development Using Two-dimensional Liquid Chromatography [C] . Qi Wang, Zhaohua Lu, Jacqueline Sharon, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：使用二维液相色谱法制备富含Francisella Turrensis LPS的富含O-抗原的糖果疫苗发育
5. Engineering a Complement Receptor-Targeted Vaccine Platform Using Francisella tularensis as a Model [D] . Tummillo, Kristen M. 2020

机译：使用Francisella Tularentsis作为模型来工程补体受体靶向疫苗平台
6. A Heterologous Prime-Boost Vaccination Strategy Comprising the Francisella tularensis Live Vaccine Strain capB Mutant and Recombinant Attenuated Listeria monocytogenes Expressing F. tularensis IglC Induces Potent Protective Immunity in Mice against Virulent F. tularensis Aerosol Challenge [O] . Qingmei Jia, Richard Bowen, Jacob Sahakian, 2013

机译：异源初免-加强免疫策略包括土拉弗朗西斯菌活疫苗株capB突变体和重组减毒表达李斯特菌的单核细胞增生李斯特菌IglC诱导小鼠对抗强毒杜拉菌的强力保护性免疫。
7. Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge [O] . Qingmei Jia, Richard Bowen, Bai-Yu Lee, 2016

机译：Francisella Tularensis从BFR启动子中缺乏载体和过表达IgLA，IgLB和IGLC的融合蛋白的富含蛋白质的活疫苗菌株诱导对F.Tularensis呼吸攻击的改进保护

Francisella tularensis vaccines. (Special Issue: Vaccines for biodefense.)

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