Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization

Licciardi P. V.; Balloch A.; Russell F. M.; Mulholland E. K.; Tang M. L. K.

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Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization

机译：婴儿肺炎球菌免疫后，血清型9V抗体表现出新型血清群交叉反应

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Cross-reactivity within the pneumococcal immune response was examined in this study. Significant cross-reactivity between serotypes 9V, 15B and 19A was identified in infant post-immunization serum that could not be effectively titrated during specific IgG measurements. Pre-absorption using serotype 9V inhibited this cross-reactivity and normalized titratability in the WHO ELISA for serotypes 15B and 19A. However, this did not affect functional avid IgG and was associated with fewer pneumococcal conjugate vaccine (PCV) doses, suggesting that cross-reactive antibodies were of low avidity. The results in this study have important implications for assessment of vaccine immunogenicity.

机译：在这项研究中检查了肺炎球菌免疫反应中的交叉反应性。在婴儿免疫后血清中鉴定出血清型9V，15B和19A之间的显着交叉反应，这些血清在特异性IgG测量期间无法有效滴定。在15W和19A型血清的WHO ELISA中，使用9V型血清的预吸收抑制了这种交叉反应性和标准化的滴定度。但是，这不会影响功能性抗体IgG，并且与较少的肺炎球菌结合疫苗（PCV）剂量相关，这表明交叉反应抗体的亲和力较低。这项研究的结果对评估疫苗的免疫原性具有重要意义。

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《Vaccine》 |2010年第22期|共8页
作者
Licciardi P. V.; Balloch A.; Russell F. M.; Mulholland E. K.; Tang M. L. K.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
immune response;

机译：免疫反应;

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1. Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization [J] . Licciardi P. V., Balloch A., Russell F. M., Vaccine . 2010,第22期

机译：婴儿肺炎球菌免疫后，血清型9V抗体表现出新型血清群交叉反应
2. Association of Serotype-Specific Antibody Concentrations and Functional Antibody Titers with Subsequent Pneumococcal Carriage in Toddlers Immunized with a 9-Valent Pneumococcal Conjugate Vaccine [J] . Birgit Simell, Anu Nurkka, Mika Lahdenkari, Clinical and vaccine immunology: CVI . 2012,第1期

机译：血清型特异性抗体浓度和功能性抗体滴度与随后接种9价肺炎球菌结合疫苗的幼儿中的肺炎球菌感染的关联。
3. Functional Antibodies to the O-Acetylated Pneumococcal Serotype 15B Capsular Polysaccharide Have Low Cross-Reactivities with Serotype 15C [J] . Gowrisankar Rajam, George M. Carlone, Sandra Romero-Steiner Clinical and vaccine immunology: CVI . 2007,第9期

机译：O乙酰化肺炎球菌血清型15B荚膜多糖的功能性抗体与血清型15C的交叉反应性低
4. CONFORMATIONAL STUDIES OF SEROGROUP 6 PNEUMOCOCCAL ANTIGENS. [C] . Mathai N. S., Ravenscroft N., Kuttel M International Carbohydrate Symposium . 2013

机译：血清群6肺炎球菌抗原的构象研究。
5. Dynamics of dengue antibodies: Transplacental transfer, decline after birth and the serotype specific response to infection among infants and children in Thailand. [D] . van Panhuis, Willem G. 2009

机译：登革热抗体的动力学：泰国婴儿和儿童中胎盘转移，出生后下降和血清型特异性感染反应。
6. Cross-Reactivity of Current Serogroup 6 Factor Sera from Statens Serum Institut with the Recently Described Pneumococcal Serotype 6D [O] . Preston E. Bratcher, Moon H. Nahm 2010

机译：史坦顿血清研究所当前血清群6因子血清与最近描述的肺炎球菌血清型6D的交叉反应性
7. Cross-Reactivity of Current Serogroup 6 Factor Sera from Statens Serum Institut with the Recently Described Pneumococcal Serotype 6D ▿ [O] . Bratcher, Preston E., Nahm, Moon H. 2010

机译：来自州立大学血清研究所的当前血清群6因子血清与最近描述的肺炎球菌血清型6D的交叉反应
8. Preventing Pneumococcal Disease among Infants and Young Children. Recommendationsof the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report, Vol. 49, No. RR-9, October 6, 2000. Recommendations and Reports [R] . Van Beneden, C. A., Whitney, C. G., Levine, O. S., 2000

机译：关于免疫规范咨询委员会（aCIp）的建议。发病率和死亡率每周报告，第49卷，第RR-9号，2000年10月6日。建议和报告

Antibodies to serotype 9V exhibit novel serogroup cross-reactivity following infant pneumococcal immunization

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