• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N-meningitidis serogroup B strains protect mice against homologous and heterologous meningococcal infection and septic shock
【24h】

Outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N-meningitidis serogroup B strains protect mice against homologous and heterologous meningococcal infection and septic shock

机译：从巴西流行的B型脑膜炎奈瑟球菌血清群中获得的外膜囊泡（OMV）和解毒的脂寡糖（dLOS）可保护小鼠免受同源和异源性脑膜炎球菌感染和败血性休克

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neisseria meningitidis (N. meningitidis) is a serious bacterial pathogen that causes life-threatening invasive bacterial infections especially in children below 2 years of age, teenagers and young adults. We have investigated the protective potential of outer membrane vesicles (OMVs) and detoxified lipooligosaccharide (dLOS) obtained from Brazilian prevalent N. meningitidis serogroup B strains. Swiss mice were immunized with different combinations of OMV and dLOS from N. meningitidis serogroup B strains compared to a reference vaccine (VA-MENGOC-BC(R), Cuba). The OMVs + dLOS from Brazilian prevalent strains induced higher bactericidal antibody titers against homologous and heterologous target strains and stronger inhibition of thrombocytopenia as compared to the reference vaccine. When the challenge was performed with the B strain, all immunogens tested showed similar survival rates (80%) significantly higher than the control group. Bacterial clearance against the group B strain was comparable for animals immunized with the tested immunogen and the reference vaccine. Inclusion of dLOS from the B strain with the OMV, induced a similar clearance of C strain bacteria as compared to VA-MENGOC-BC(R). The immunogens, as well as the reference vaccine drastically inhibited increases in TNF-alpha and IL-6 plasma levels after challenge. In conclusion, the OMV/dLOS formulation obtained from Brazilian prevalent strains of N. meningitidis has a remarkable performance protecting mice against the lethal effects of meningococcal challenge showing a good potential as a vaccine and should be considered for clinical evaluation.
机译：脑膜炎奈瑟氏球菌（N. meningitidis）是一种严重的细菌病原体，会导致威胁生命的侵入性细菌感染，尤其是在2岁以下的儿童，青少年和年轻人中。我们已经调查了从巴西流行性脑膜炎双球菌血清群B菌株获得的外膜囊泡（OMV）和解毒的脂寡糖（dLOS）的保护潜力。与参考疫苗（VA-MENGOC-BC（R），古巴）相比，用来自脑膜炎双球菌血清群B株的OMV和dLOS的不同组合免疫瑞士小鼠。与参考疫苗相比，来自巴西流行株的OMVs + dLOS诱导了针对同源和异源靶标菌株的更高的杀菌抗体滴度，以及对血小板减少症的更强抑制作用。当用B株进行攻击时，所有测试的免疫原均显示出相似的存活率（80％），显着高于对照组。对于用测试的免疫原和参考疫苗免疫的动物，其对B组毒株的细菌清除率相当。与VA-MENGOC-BC（R）相比，用OMV将B菌株中的dLOS包括在内，可诱导C菌株细菌的清除率相似。攻击后，免疫原和参考疫苗均能显着抑制TNF-α和IL-6血浆水平的升高。总之，从巴西脑膜炎奈瑟氏球菌流行株获得的OMV / dLOS制剂具有出色的性能，可保护小鼠免受脑膜炎球菌攻击的致死作用，显示出作为疫苗的良好潜力，应考虑用于临床评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号