In vitro stimulation of human influenza-specific CD8(+) T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine

Song Haifeng; Wittman Vaughan; Byers Anthony; Tapia Tenekua; Zhou Bin; Warren William; Heaton Penny Author; E-mail: penny.heaton@novartis.com; Connolly Kevin Author Reprint Author; E-mail: kconnolly@novavax.com.

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In vitro stimulation of human influenza-specific CD8(+) T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine

机译：流感病毒样颗粒（VLP）疫苗脉冲刺激的树突状细胞体外刺激人流感特异性CD8（+）T细胞

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The purpose of this in vitro study was to determine if a virus-like particle (VLP) influenza vaccine stimulated human CM T cells in a dendritic cell (DC): T cell co-culture system. VLP-pulsed DCs were co-cultured with autologous CD8(+) T cells from five donors. Functional CD8(+) T cells were detected via cell surface and intracellular cytokine staining. T cells from four of the five donors showed >= 2-fold increase over background in the % activated CD8(+). cells. These results indicate that the influenza VLP vaccine can stimulate CD8(+) T cells via DC antigen presentation, likely through the MHC-I pathway, thus broadening the immunological response induced by this promising influenza vaccine

机译：这项体外研究的目的是确定树状细胞（DC）：T细胞共培养系统中的病毒样颗粒（VLP）流感疫苗是否刺激了人CM T细胞。 VLP脉冲的DC与来自五个供体的自体CD8（+）T细胞共培养。通过细胞表面和细胞内细胞因子染色检测功能性CD8（+）T细胞。来自五个供体中四个的T细胞在％活化的CD8（+）中显示出比背景高出> = 2倍。细胞。这些结果表明，流感VLP疫苗可能通过MHC-I途径通过DC抗原呈递刺激CD8（+）T细胞，从而扩大了这种有前途的流感疫苗诱导的免疫应答

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《Vaccine》 |2010年第34期|共9页
作者
Song Haifeng; Wittman Vaughan; Byers Anthony; Tapia Tenekua; Zhou Bin; Warren William; Heaton Penny Author; E-mail: penny.heaton@novartis.com; Connolly Kevin Author Reprint Author; E-mail: kconnolly@novavax.com.;
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正文语种 eng
中图分类医学免疫学;
关键词
interferon-gamma: IFN-gamma; antigen; MHC-I; trivalent virus-like particle influenza vaccine: Novavax; immunologic-drug; immunostimulant-drug; va; immunological response;

机译：干扰素-γ：IFN-γ;抗原;MHC-1;三价病毒样颗粒流感疫苗：Novavax;免疫药物;免疫刺激药物;va;免疫应答;

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1. In vitro stimulation of human influenza-specific CD8(+) T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine [J] . Song Haifeng, Wittman Vaughan, Byers Anthony, Vaccine . 2010,第34期

机译：流感病毒样颗粒（VLP）疫苗脉冲刺激的树突状细胞体外刺激人流感特异性CD8（+）T细胞
2. Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7. [J] . Nonn M, Schinz M, Zumbach K, Journal of Cancer Research and Clinical Oncology . 2003,第9期

机译：宫颈癌的基于树突细胞的肿瘤疫苗I：重组蛋白脉冲树突细胞的体外刺激可诱导HPV16 E7或HPV18 E7的特异性T细胞。
3. Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7 [J] . Marion Nonn, Manuela Schinz, Klaus Zumbach, Journal of Cancer Research and Clinical Oncology . 2003,第9期

机译：宫颈癌的基于树突细胞的肿瘤疫苗I：重组蛋白脉冲树突细胞的体外刺激可诱导HPV16 E7或HPV18 E7的特异性T细胞
4. IMMUNIZATION OF DENDRITIC CELLS PULSED WITH PRRS VIRUS GP5 PROTEIN INDUCES CD4+ BUT NOT CD8+ T CELLS [C] . Nguyen-Dinh Quat, Jeongran Min, Jiwon Han, Congress ofthe International Pig Veterinary Society . 2008

机译：用PRRS病毒GP5蛋白脉冲树突细胞的免疫诱导CD4 +但不是CD8 + T细胞
5. Dendritic cells and Langerhans cells respond differently to human papillomavirus virus-like particles: Consequences for human papillomavirus vaccine development. [D] . Fausch, Steven Charles. 2004

机译：树突状细胞和朗格汉斯细胞对人乳头瘤病毒样病毒颗粒的反应不同：人乳头瘤病毒疫苗开发的后果。
6. Human Papillomavirus Type 16 (HPV-16) Virus-Like Particle L1-Specific CD8+ Cytotoxic T Lymphocytes (CTLs) Are Equally Effective as E7-Specific CD8+ CTLs in Killing Autologous HPV-16-Positive Tumor Cells in Cervical Cancer Patients: Implications for L1 Dendritic Cell-Based Therapeutic Vaccines [O] . Stefania Bellone, Karim El-Sahwi, Emiliano Cocco, 2009

机译：人乳头瘤病毒16型（HPV-16）病毒样L1特异性CD8 +细胞毒性T淋巴细胞（CTL）与E7特异性CD8 + CTL一样有效地杀死宫颈癌患者的自体HPV-16阳性肿瘤细胞：对L1的影响基于树突状细胞的治疗疫苗
7. CD8 CD11b+ dendritic cells present exogenous virus-like particles (VLPs) to CD8+ T cells and express CD8 and DEC205 molecules [O] . Morón, Gabriel L., Rueda, Paloma, Casal, J. Ignacio, 2002

机译：CD8CD11b +树突状细胞将外源病毒样颗粒（VLP）呈现给CD8 + T细胞，并表达CD8和DEC205分子
8. Ebola and Marburg Virus-Like Particles Activate Human Myeloid Dendritic Cells [R] . Bosio, C. M. , Moore, B. D. , Warfield, K. L. , 2004

机译：埃博拉和马尔堡病毒样颗粒激活人类骨髓树突状细胞

In vitro stimulation of human influenza-specific CD8(+) T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine

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