Circumvention of MHC class II restriction by genetic immunization

Schuler K; Lu C; Chang HD; Croft M; Zanetti M; Gerloni M

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Circumvention of MHC class II restriction by genetic immunization

机译：通过基因免疫规避II类MHC限制

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The fate of T cell responses to peptide-based vaccination is subject to constraints by the major histocompatibility complex (MHC), MHC restriction. Using as a model system of T and B cell epitopes from the circumsporozoite protein of Plasmodium falciparum malaria parasite, we show that vaccination by somatic transgene immunization readily primes Balb/c mice (H-2(d)) a strain previously reported to be non-responder to immunization with a synthetic peptide vaccine encompassing these epitopes. Following genetic vaccination Balb/c mice developed a primary T cell response comparable to that of the responder strain C57B1/6 (H-2(b)). Following booster immunization on day 45 Balb/c mice responded with a typical T cell memory response. Priming induced the formation of specific antibodies, which rose sharply after booster immunization. These findings suggests that genetic immunization can circumvent MHC class II restriction.

机译：T细胞对基于肽的疫苗接种反应的命运受到主要组织相容性复合物（MHC）的限制，即MHC限制。使用恶性疟原虫疟原虫的环子孢子蛋白的T和B细胞表位作为模型系统，我们显示通过体细胞转基因免疫接种很容易引发Balb / c小鼠（H-2（d））先前报道是非-对包含这些表位的合成肽疫苗的免疫应答。基因疫苗接种后，Balb / c小鼠产生了与应答株C57B1 / 6（H-2（b））相当的原代T细胞应答。在第45天加强免疫后，Balb / c小鼠产生典型的T细胞记忆反应。引物诱导形成特异性抗体，在加强免疫后急剧上升。这些发现表明，基因免疫可以绕开II类MHC限制。

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来源
《Vaccine》 |2001年第4期|共5页
作者
Schuler K; Lu C; Chang HD; Croft M; Zanetti M; Gerloni M;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Genetic immunization; Malaria; Mhc class ii; T-cell epitopes; Falciparum circumsporozoite protein; Somatic transgene; immunization; Defined synthetic vaccine; B-cell; Dna immunization; Malaria vaccine; In-vivo; Molecules; Peptides;

机译：基因免疫;疟疾;Mhc ii类;T细胞表位;恶性环孢子蛋白;体细胞转基因;免疫;确定的合成疫苗;B细胞;Dna免疫;疟疾疫苗;体内;分子;肽;

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专利

1. Circumvention of MHC class II restriction by genetic immunization [J] . Schuler K, Lu C, Chang HD, Vaccine . 2001,第3a4期

机译：通过基因免疫规避II类MHC限制
2. Human CD4+ T cells lyse target cells via granzyme/perforin upon circumvention of MHC class II restriction by an antibody-like immunoreceptor. [J] . Hombach A, Kohler H, Rappl G, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2006,第8期

机译：人CD4 + T细胞在通过抗体样免疫受体规避MHC II类限制后，通过颗粒酶/穿孔素裂解靶细胞。
3. Human CD4+ T Cells Lyse Target Cells via Granzyme/Perforin upon Circumvention of MHC Class II Restriction by an Antibody-Like Immunoreceptor [J] . Andreas Hombach, Heike K?hler, Gunter Rappl, The journal of immunology . 2006,第8期

机译：人类的CD4 + T细胞通过类似于抗体的免疫受体规避MHC II类限制后，通过颗粒酶/穿孔素裂解靶细胞。
4. CLASSIFICATION USING NEGATIVE SELECTION ALGORITHM: APPLICATION TO MHC CLASS II BINDERS /NON-BINDERS USED IN PEPTIDE BASED VACCINE DESIGNING [C] . S. S. SOAM, FEROZ KHAN, B. BHASKER, International Conference on Computer and Automation Engineering . 2012

机译：使用负选择算法进行分类：应用于MHC II类粘合剂/非粘合剂的肽基于肽的疫苗设计
5. The MHC class II associated invariant chain limits the immunogenicity of genetically modified human tumor cell vaccines. [D] . Thompson, James Andrew. 2007

机译：MHC II类相关的恒定链限制了转基因人类肿瘤细胞疫苗的免疫原性。
6. MHC class II-bound self-peptides can be effectively separated by isoelectric focusing and bind optimally to their MHC class II restriction elements around pH 5.0. [O] . S Mouritsen, I Dalum, A M Engel, 1994

机译：MHC II类结合的自肽可以通过等电聚焦有效分离并在pH 5.0左右最佳地结合到其MHC II类限制元件上。
7. Human CD4+T Cells Lyse Target Cells via Granzyme/Perforin upon Circumvention of MHC Class II Restriction by an Antibody-Like Immunoreceptor [O] . Andreas Hombach, Heike Köhler, Gunter Rappl, 2006

机译：人体CD4 + T细胞通过抗体样免疫感应的MHC类II限制，通过Granzzyme / Perforin叙述靶细胞。
8. Circumventing Genetic Restriction of Protection against Malaria with MultigeneDNA Immunization: CD8+ T Cell-, Inteferon and Nitric Oxide-Dependent Immunity [R] . Doolan, D. L., Sedegah, M., Hedstrom, R. C., 1996

机译：通过多基因免疫接种来规避疟疾的遗传限制：CD8 + T细胞，干扰素和一氧化氮依赖性免疫

Circumvention of MHC class II restriction by genetic immunization

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