Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides

Langhans B; Braunschweiger I; Schweitzer S; Sauerbruch T; Spengler U

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Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides

机译：脂化肽对丙型肝炎病毒（HCV）特异性抗体产生B细胞的初次免疫

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We analysed whether hepatitis C virus (HCV)-specific antibody producing B lymphocytes can be induced in vitro with HCV-derived lipopeptides containing different T helper cell epitopes. HCV-specific antibody producing B cells were detected by ELISPOT at the single cell level. HCV-derived lipopeptides, but not their corresponding unlipidated peptides, induced B lymphocytes, which produced antibodies mainly reacting with the HCV-derived lipopeptides. The number of antigen-specific B cells was dependent on the number of added autologous T helper lymphocytes during the incubation period. Thus, HCV lipopeptides are more immunogenic than unmodified peptides and can induce HCV-reactive B lymphocytes in antigen-naive lymphocytes

机译：我们分析了丙型肝炎病毒（HCV）特异性抗体产生的B淋巴细胞是否可以在体外用包含不同T辅助细胞表位的HCV衍生脂肽诱导。通过ELISPOT在单细胞水平上检测到产生HCV特异性抗体的B细胞。 HCV衍生的脂肽而非其相应的未脂化肽诱导了B淋巴细胞，后者产生的抗体主要与HCV衍生的脂肽起反应。抗原特异性B细胞的数量取决于孵育期间添加的自体T辅助淋巴细胞的数量。因此，HCV脂肽比未修饰的肽具有更高的免疫原性，并且可以在天然抗原的淋巴细胞中诱导HCV反应性B淋巴细胞

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来源
《Vaccine》 |2004年第12期|共7页
作者
Langhans B; Braunschweiger I; Schweitzer S; Sauerbruch T; Spengler U;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Hcv-derived lipopeptide; Primary b cell response; Elispot technique; Human monoclonal-antibodies; Blood mononuclear-cells; In-vitro; immunization; Leucine methyl-ester; Toll-like receptors; T-cell; Lipopeptide vaccine; Immune-response; Lymphocytes; Infection;

机译：源自Hcv的脂肽;原代b细胞反应;Elispot技术;人类单克隆抗体;血液单核细胞;体外;免疫接种;亮氨酸甲酯;Toll样受体;T细胞;脂肽疫苗;免疫反应;淋巴细胞;感染;

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专利

1. Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides [J] . Langhans B, Braunschweiger I, Schweitzer S, Vaccine . 2004,第11a12期

机译：脂化肽对丙型肝炎病毒（HCV）特异性抗体产生B细胞的初次免疫
2. Measurements of HCV neutralizing antibodies and of HCV-specific CD4+ and CD8+ cells using hepatitis C virus pseudo-particles (HCVpp). [J] . Berger A, Giroglou T, Leutz A, Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology . 2009,第1期

机译：使用丙型肝炎病毒假颗粒（HCVpp）测量HCV中和抗体以及HCV特异性CD4 +和CD8 +细胞。
3. Hepatitis C virus (HCV)-specific in vitro antibody secretion by peripheral blood lymphocytes: correlation with progression of disease and HCV RNA in HCV antibody-positive patients. [J] . J Ducos, A M Bianchi-Mondain, M Francois, Journal of Clinical Microbiology . 1994,第10期

机译：丙型肝炎病毒（HCV）特异性的外周血淋巴细胞体外抗体分泌：与HCV抗体阳性患者的疾病进展和HCV RNA相关。
4. Characterization of monoclonal antibodies produced by hybridoma cell lines prepared against hepatitis B virus X protein [C] . Mi-Kyung Chung, Hee Gu Lee, Eun Suk Oh, Annual Meeting of the Japanese Association for Animal Cell Technology . 1998

机译：用丙肝炎病毒X蛋白制备的杂交瘤细胞系产生单克隆抗体的表征
5. Hepatitis C virus (HCV) replication in vitro and the effect of HCV on human immunodeficiency virus (HIV-1) coreceptor usage and diversity in the coinfected patient. [D] . Franco, Kelly Flory. 2007

机译：丙型肝炎病毒（HCV）的体外复制以及HCV对合并感染患者中人免疫缺陷病毒（HIV-1）共受体使用和多样性的影响。
6. Hepatitis C Virus (HCV)-Specific CD8+ Cells Produce Transforming Growth Factor β That Can Suppress HCV-Specific T-Cell Responses [O] . Nadia Alatrakchi, Camilla S. Graham, Hans J. J. van der Vliet, 2007

机译：丙型肝炎病毒（HCV）特异性CD8 +细胞产生可抑制HCV特异性T细胞应答的转化生长因子β
7. Hepatitis C Virus (HCV)-Specific CD8+ Cells Produce Transforming Growth Factor β That Can Suppress HCV-Specific T-Cell Responses▿ [O] . Alatrakchi, Nadia, Graham, Camilla S., van der Vliet, Hans J. J., 2007

机译：丙型肝炎病毒（HCV）特异性CD8 +细胞产生可抑制HCV特异性T细胞反应的转化生长因子βGrowth
8. Virus-Specific Antibody-Producing Cells in Blood and Cerebrospinal Fluid in Acute Japanese Encephalitis [R] . Burke, D. S., Nisalak, A., Lorsomrudee, W., 1985

机译：急性日本脑炎患者血液和脑脊液中的病毒特异性抗体产生细胞

Primary immunisation of hepatitis C virus (HCV)-specific antibody producing B cells by lipidated peptides

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