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Protection of cynomolgus monkeys against HEV infection by oral administration of recombinant hepatitis E virus-like particles

机译：口服重组戊型肝炎病毒样颗粒保护食蟹猴免受戊型肝炎病毒感染

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Hepatitis E virus (HEV) is an important causative agent of enterically-transmitted hepatitis. Successful vaccine development is crucial in controlling global HEV infection. HEV capsid protein, with I I I amino acids truncated at the N-terminus, was efficiently expressed in the baculovirus expression system [J. Virol. 71 (1997) 7207-13]. Expressed protein spontaneously assembled into virus-like particles (VLPs) and was released into culture medium. When cynomolgus monkeys were orally inoculated with 10 mg of purified rHEV VLPs, serum IgM, IgG, and IgA responses were observed. All these antibody responses were obtained without adjuvants. When the monkeys were challenged with native HEV by intravenous injection, they were protected against infection or developing hepatitis. These results suggested that recombinant HEV (rHEV) VLPs can be a candidate for the oral hepatitis E vaccine
机译：戊型肝炎病毒（HEV）是肠道传播型肝炎的重要病原体。成功开发疫苗对于控制全球HEV感染至关重要。杆状病毒表达系统有效表达了HEV衣壳蛋白，在N端截短了我的氨基酸。病毒。 71（1997）7207-13]。表达的蛋白质自发地组装成病毒样颗粒（VLP），并释放到培养基中。食蟹猕猴经口服10 mg纯化的rHEV VLP接种后，观察到血清IgM，IgG和IgA反应。在没有佐剂的情况下获得了所有这些抗体应答。当猴子通过静脉注射天然HEV攻击时，它们被保护免受感染或发展为肝炎。这些结果表明，重组HEV（rHEV）VLP可以作为口服戊型肝炎疫苗的候选药物

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