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The implication of a reduced-dose hepatitis B vaccination schedule in low risk newborns

机译：低剂量新生儿乙肝疫苗减量接种计划的含义

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Five hundred and seventy-four babies born to HBsAg negative mothers in Hong Kong received either a regular (5 mug) or reduced (2.5 mug) three-dose regimen of recombinant hepatitis B vaccine. A significantly higher anti-HBs positivity rate (greater than or equal to 10 mIU/ml), geometric mean titer (GMT) and the maintenance of a high anti-HBs level (greater than or equal to 100 mIU/ml) were observed with the regular-dose regimen. The differences persisted, however, only up to 1 year post-vaccination. Over an 8-year period, only 1% of the vaccinees demonstrated anti-HBc seroconversion and none had become HBsAg positive. The long-term efficacy of the reduced-dose regimen was confirmed, even in an HBV endemic population.
机译：在香港，有574名HBsAg阴性母亲所生的婴儿接受了常规（5杯）或减量（2.5杯）三剂重组乙型肝炎疫苗治疗。观察到，抗HBs阳性率（大于或等于10 mIU / ml），几何平均滴度（GMT）和高抗HBs水平维持（大于或等于100 mIU / ml）明显更高。常规剂量的方案。但是，这种差异一直持续到疫苗接种后长达一年。在8年的时间里，只有1％的疫苗表现出抗HBc血清转化，没有一个成为HBsAg阳性。即使在HBV流行人群中，也证实了减剂量方案的长期疗效。

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