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首页> 外文期刊>Vaccine >Decreased shedding of Escherichia coli O157 : H7 by cattle following vaccination with type III secreted proteins
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Decreased shedding of Escherichia coli O157 : H7 by cattle following vaccination with type III secreted proteins

机译：牛接种III型分泌蛋白后，大肠杆菌O157：H7的脱落减少

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Cattle are an important reservoir of Escherichia coli O157:H7 leading to contamination of food and water, and subsequent human disease. This pathogen colonizes its hosts by producing several proteins such as Tir and EspA that are secreted by a type III secretion system. These proteins play a role in colonization of the intestine, suggesting that they might be useful targets for the development of a vaccine to reduce levels of this organism in cattle. Vaccination of cattle with proteins secreted by E. coli 0157:H7 significantly reduced the numbers of bacteria shed in feces, the numbers of animals that shed, and the duration of shedding in an experimental challenge model. Vaccination of cattle also significantly (P = 0.04) reduced the prevalence of E. coli 0157:H7 in a clinical trial conducted in a typical feedlot setting. This strategy suggests it is possible to vaccinate cattle to decrease the level of E. coli 0157:H7 shedding for the purpose of reducing the risk of human disease
机译：牛是大肠杆菌O157：H7的重要储存库，导致食物和水的污染以及随后的人类疾病。该病原体通过产生几种蛋白质（例如由III型分泌系统分泌的Tir和EspA）来定居其宿主。这些蛋白质在肠道定殖中起作用，表明它们可能是开发疫苗以降低牛体内这种生物体水平的有用靶标。用大肠杆菌0157：H7分泌的蛋白质对牛进行疫苗接种可大大减少粪便中细菌的数量，动物的数量以及实验性攻击模型中脱落的持续时间。在典型的饲养场环境中进行的临床试验中，牛的疫​​苗接种也显着降低（P = 0.04）E. coli 0157：H7的患病率。此策略表明，可以接种牛疫苗以降低大肠杆菌0157：H7的脱落水平，以降低人类疾病的风险

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