...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Interfering vaccine: a novel antiviral that converts a potentially virulent infection into one that is subclinical and immunizing
【24h】

Interfering vaccine: a novel antiviral that converts a potentially virulent infection into one that is subclinical and immunizing

机译：干扰疫苗：一种新型抗病毒药，可将潜在的强毒感染转变为亚临床和免疫接种

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Infection with human influenza A virus can reach cataclysmic levels, with 40 or more million deaths arising from the 1918 pandemic. Preventative and therapeutic measures have improved since that time, but new approaches are needed. Here, we describe one such new approach-the interfering vaccine, which has two activities-it prophylactically prevents influenza, and at the same time converts an otherwise lethal infection into one that is avirulent and immunizing. Mice treated in this way develop a solid immunity that protects them against a subsequent challenge with homologous virus, and to a lesser extent from challenge with heterologous influenza A viruses. The interfering vaccine comprises non-infectious, defective interfering (DI) influenza A virus. Prophylaxis is mediated directly by DI RNA, and results from interference with the replication of the infecting virus. However, interference is incomplete, and there is sufficient wild-type virus multiplication to stimulate a virus-specific natural immunity. As the replication mechanism is common to all influenza A viruses, an interfering vaccine should protect from, and permit immunity to be developed to all influenza A viruses. Indeed, we demonstrate protection against two viruses with antigenically unrelated HA and NA proteins. Thus an interfering vaccine, unlike the conventional vaccine, is independent of the antigenicity of the infecting virus. In principle, interfering vaccines derived from other virus systems could also be developed.
机译：人类甲型流感病毒的感染可达到破坏性的水平，1918年的大流行导致40万人或更多的死亡。自那时以来，预防和治疗措施已有所改善，但是需要新的方法。在这里，我们描述了一种这样的新方法-具有两种活性的干扰疫苗-预防性预防流感，同时将原本致命的感染转化为无毒和免疫的感染。用这种方法处理过的小鼠产生了坚实的免疫力，可以保护它们免受随后的同源病毒攻击，并在较小程度上免受异源甲型流感病毒的攻击。干扰疫苗包含非传染性，有缺陷的干扰（DI）甲型流感病毒。预防直接由DI RNA介导，其结果是干扰感染病毒的复制。但是，干扰是不完全的，并且有足够的野生型病毒繁殖来刺激病毒特有的自然免疫力。由于复制机制是所有A型流感病毒所共有的，因此干扰疫苗应能保护所有A型流感病毒并使其免疫。实际上，我们证明了针对两种与抗原无关的HA和NA蛋白的病毒的保护作用。因此，与常规疫苗不同，干扰疫苗独立于感染病毒的抗原性。原则上，也可以开发源自其他病毒系统的干扰疫苗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号