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The projected health benefits of maternal group B streptococcal vaccination in the era of chemoprophylaxis

机译：化学预防时代孕妇B型链球菌疫苗接种对健康的预期影响

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While maternal antibiotic prophylaxis has greatly reduced early-onset group B streptococcal (GBS) disease in the United States, a GBS vaccine currently under development could potentially prevent additional GBS cases and preterm births. A decision analytic model was created to compare preventive strategies using adolescent, maternal (prenatal), or postpartum vaccination with selective chemoprophylactic strategies. The current practice of culture-based chemoprophylaxis was predicted to prevent 55% of early plus late-onset GBS infections. Maternal vaccination strategies were superior to current practice, preventing 68-69% of all GBS infections and 4% of very preterm births (<32 weeks gestation). The most effective adolescent vaccination strategy combined vaccination with culture-based chemoprophylaxis for all women and prevented 66% of all GBS infections. All other strategies were similar in efficacy to current practice or inferior. Maternal GBS vaccination is predicted to prevent more cases of neonatal GBS disease than current practice and would prevent approximately one in 25 very preterm births.
机译：尽管在美国，孕妇预防性使用抗生素已大大减少了B组早期链球菌（GBS）疾病，但目前正在开发的GBS疫苗可能会阻止其他GBS病例和早产。建立了决策分析模型，以比较青少年，母亲（产前）或产后疫苗接种的预防策略与选择性化学预防策略的比较。预计基于培养物的化学预防的当前实践可预防55％的早期和晚期GBS感染。孕产妇疫苗接种策略优于目前的疫苗接种策略，可预防68-69％的所有GBS感染和4％的早产（小于32周妊娠）。最有效的青少年疫苗接种策略是对所有妇女进行疫苗接种与基于文化的化学预防相结合，并预防了所有GBS感染的66％。所有其他策略在功效上都与当前实践相似或逊色。预计孕妇GBS疫苗接种将比目前的实践预防更多的新生儿GBS疾病病例，并且将预防大约25个早产婴儿。

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