Mucosal immunization against hepatitis A: Antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid

Mitchell LA; Joseph A; Kedar E; Barenholz Y; Galun E

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Mucosal immunization against hepatitis A: Antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid

机译：甲型肝炎的粘膜免疫：合成寡聚脱氧核苷酸和新型阳离子脂质的共同给药可增强抗体应答

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Hepatitis A caused by hepatitis A virus (HAV) transmitted by the fecal-oral route, results in considerable morbidity and economic loss. Mucosal immunization can be more effective than conventional injection at inducing both local and systemic immunity to HAV. Here we show that co-administration of killed HAV with synthetic oligodeoxynucleotides (ODNs) containing CpG sequences, and a novel polycationic sphingolipid (CCS)/cholesterol liposomal delivery system, markedly enhances the HAV-specific antibody response at the intestinal interface, particularly when delivered intrarectally or intranasally, to Balb/c mice at low HAV doses. A mucosally delivered, antigen-sparing HAV vaccine that is easily administered without specialized equipment or personnel, is an attractive alternative for facilitating mass immunization in hepatitis A outbreaks.

机译：粪便途径传播的甲型肝炎病毒（HAV）引起的甲型肝炎导致相当大的发病率和经济损失。黏膜免疫可以比常规注射更有效地诱导针对HAV的局部和全身免疫。在这里，我们显示杀死的HAV与含有CpG序列的合成寡聚脱氧核苷酸（ODN）以及新型的聚阳离子鞘脂（CCS）/胆固醇脂质体递送系统共同给药，可显着增强肠道界面上的HAV特异性抗体应答，尤其是在递送时低HAV剂量对Balb / c小鼠进行直肠内或鼻内给药。粘膜递送的保留抗原的HAV疫苗无需专业设备或人员即可轻松施用，是促进甲型肝炎暴发大规模免疫的有吸引力的替代方法。

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《Vaccine》 |2006年第25期|共11页
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Mitchell LA; Joseph A; Kedar E; Barenholz Y; Galun E;
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中图分类卫生标准、卫生检查、医药管理;
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1. Mucosal immunization against hepatitis A: Antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid [J] . Mitchell LA, Joseph A, Kedar E, Vaccine . 2006,第25期

机译：甲型肝炎的粘膜免疫：合成寡聚脱氧核苷酸和新型阳离子脂质的共同给药可增强抗体应答
2. Vigorous hepatitis C virus-specific CD4+ and CD8+ T cell responses induced by protein immunization in the presence of Montanide ISA720 plus synthetic oligodeoxynucleotides containing immunostimulatory cytosine-guanine dinucleotide motifs. [J] . Sugauchi F, Wang RY, Qiu Q, The Journal of Infectious Diseases . 2006,第4期

机译：在Montanide ISA720加上含有免疫刺激性胞嘧啶-鸟嘌呤二核苷酸基序的合成寡脱氧核苷酸的存在下，通过蛋白质免疫诱导的强烈丙型肝炎病毒特异性CD4 +和CD8 + T细胞反应。
3. Vigorous Hepatitis C Virus—Specific CD4+ and CD8+ T Cell Responses Induced by Protein Immunization in the Presence of Montanide ISA720 plus Synthetic Oligodeoxynucleotides Containing Immunostirnulatory Cytosine-Guanine Dinucleotide Motifs [J] . Fuminaka Sugauchi, Richard Y.-H. Wang, Qi Qiu, Journal of Infectious Diseases . 2006,第4期

机译：在Montanide ISA720加上含有免疫刺激性胞嘧啶-鸟嘌呤二核苷酸基序的合成寡聚脱氧核苷酸的情况下，蛋白免疫诱导的剧烈C型肝炎病毒-特定的CD4 + 和CD8 + T细胞反应
4. Stability of oligodeoxynucleotide complexes with cationic phospholipid and peptide carriers [C] . B.G. Tenchov, R. Koynova, R.W. Ahn, NSTI-Nanotech 2010;NSTI nanotechnology conference and expo;Bio Nanotech 2010;NSTI bio nano conference and expo;Microtech 2010;Microtechnology conference and expo;WCM 2010;Workshop on compact modeling;NSTI nanotech ventures;TechConnect summit;Clean technology . 2010

机译：寡脱氧核苷酸复合物与阳离子磷脂和肽载体的稳定性
5. Mucosal immunization for augmented mucosal immune responses in chickens. [D] . Greenway, Terrence. 2005

机译：鸡进行粘膜免疫以增强粘膜免疫反应。
6. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 Agonist, Promotes Potent Systemic and Mucosal Responses to Intranasal Immunization with HIVgp140 [O] . Mauricio A. Arias, Griet A. Van Roey, John S. Tregoning, 2009

机译：Glucopyranosyl脂质佐剂（GLA），一种合成的TLR4激动剂，可促进对HIVgp140鼻内免疫的有效全身和粘膜反应
7. Vigorous Hepatitis C Virus–Specific CD4+and CD8+T Cell Responses Induced by Protein Immunization in the Presence of Montanide ISA720 plus Synthetic Oligodeoxynucleotides Containing Immunostimulatory Cytosine‐Guanine Dinucleotide Motifs [O] . Fuminaka Sugauchi, Richard Y.‐H. Wang, Qi Qiu, 2006

机译：在蒙吡酰岛ISA720加上含有免疫刺激性胞嘧啶 - 鸟嘌呤二核苷酸基序的蛋白质免疫，蛋白质免疫诱导的蛋白质免疫诱导的巨大丙型肝炎病毒的CD4 +和CD8 + T细胞应答

Mucosal immunization against hepatitis A: Antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid

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