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首页> 外文期刊>Vaccine >Effectiveness of influenza vaccination in preventing influenza-like illness among community-dwelling elderly: Population-based cohort study in Japan
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Effectiveness of influenza vaccination in preventing influenza-like illness among community-dwelling elderly: Population-based cohort study in Japan

机译：流感疫苗预防在社区老年人中预防流感样疾病的有效性：日本基于人群的队列研究

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A population-based cohort study was conducted during the 2003-2004 season to examine the effectiveness of influenza vaccine among community-dwelling elderly. The subjects consisted of 4787 elderly, ranging from 65 to 79 years. We either interviewed the elderly directly or their families regarding acute febrile illness, hospital visits, hospitalization and death by telephone every month. The vaccination status and physician-diagnosed clinical influenza (hereinafter referred as clinical influenza) were determined based on data obtained from the city office and hospitals, respectively. Influenza-like illness (ILI) was defined as an acute febrile illness (/=38.5 degrees C) during the epidemic period. After adjusting for confounders, vaccination decreased ILI significantly (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.17-0.85), but not clinical influenza (OR, 0.76; 95% CI, 0.28-2.06). The results were inconclusive for preventing hospitalization for influenza or pneumonia (OR, 0.37; 95% CI, 0.09-1.47) and death (OR, 3.68; 95% CI, 0.75-18.12), due to the inadequate sample size. In conclusion, the influenza vaccination was thus found to be associated with a decreased ILI during the epidemic period in community-dwelling elderly.
机译：在2003年至2004年季节进行了一项基于人群的队列研究，以检查流感疫苗在社区居民中的有效性。受试者包括4787名年龄在65至79岁之间的老年人。我们每月都会通过电话直接采访老人或他们的家人有关急性发热疾病，就诊，住院和死亡的信息。根据分别从市政府和医院获得的数据确定疫苗接种状况和医生诊断的临床流感（以下简称临床流感）。流感样疾病（ILI）被定义为流行期间的一种急性发热性疾病（> / = 38.5摄氏度）。调整混杂因素后，疫苗接种可显着降低ILI（几率[OR]为0.38; 95％置信区间[CI]为0.17-0.85），但临床流感则没有（OR为0.76; 95％CI为0.28-2.06）。由于样本量不足，结果无法预防流感或肺炎（OR，0.37; 95％CI，0.09-1.47）和死亡（OR，3.68; 95％CI，0.75-18.12）的住院。总之，因此，在社区居民中，在流行期间流感疫苗接种与ILI降低有关。

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