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Basic principle of population-based cohort study to evaluate influenza vaccine effectiveness among elderly Japanese

机译：人口群体研究基本原理评价日本老年人流感疫苗效应

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摘要

Influenza vaccines minimize the risk of influenza-related morbidity, complication, and death in elderly people. Although evaluating vaccine effectiveness (VE) is important for promoting immunization programs and coping with influenza epidemics, it is difficult to evaluate its effectiveness in Japan, where no frameworks to use large databases, such as a vaccination registry and health maintenance organization datasets, are available. Therefore, another analytic epidemiological investigations to evaluate VE in Japan are required. Herein, we describe the basic principles of a cohort study, which might be the most comprehensive, but expensive, study design. It is particularly important to be aware of the potential bias and confounding factors that should be minimized in the study design and analysis. We focus on "laboratory-confirmed influenza" and "influenza-like illness", and discuss why it is important to follow up with equal intensity, and how to control for bias; problems that often arise in population-based observational cohort studies. (C) 2017 Elsevier Ltd. All rights reserved.
机译：流感疫苗最大限度地减少了老年人流感相关的发病率，并发症和死亡的风险。虽然评估疫苗效率（VE）对于促进免疫计划和应对流感流行病来说，很难评估其在日本的有效性，但没有使用大型数据库的框架，例如疫苗登记处和健康维护组织数据集。 。因此，需要在日本评估ve的另一种分析流行病学调查。在此，我们描述了群组研究的基本原则，这可能是最全面的，但昂贵的学习设计。要意识到在研究设计和分析中应该最小化的潜在偏差和混杂因素尤为重要。我们专注于“实验室证实的流感”和“流感样疾病”，并讨论为什么以平等强度跟进，以及如何控制偏见是重要的;基于人口的观察队合研究中经常出现的问题。 （c）2017 Elsevier Ltd.保留所有权利。

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