...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Molybdenum and tungsten enzymes: a crystallographic and mechanistic overview
【24h】

Molybdenum and tungsten enzymes: a crystallographic and mechanistic overview

机译：钼和钨酶：晶体学和机理概述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Molybdenum and tungsten enzymes which contain the pyranopterin cofactor are ubiquitous in Nature and perform a wide variety of biological functions. They catalyze a diversity of mostly two-electron oxidation-reduction reactions crucial in the metabolism of nitrogen, sulfur and carbon. These enzymes share common structural features, but reveal different polypeptide folding topologies and different active site coordination geometries, which, in part, dictate their function and specificity. On the basis of structural, spectroscopic and biochemical characteristics, they have been classified into three broad families named according to well-studied enzymes of each family: xanthine oxidase, sulfate oxidase and DMSO reductase. An overview of the X-ray crystallography data for representative members of the three enzyme families is given here, focusing on the mechanistic implications drawn from the structural data.
机译：含有吡喃蝶呤辅助因子的钼和钨酶在大自然中普遍存在，并具有多种生物学功能。它们催化多种主要对氮，硫和碳代谢至关重要的双电子氧化还原反应。这些酶具有共同的结构特征，但是揭示不同的多肽折叠拓扑和不同的活性位点配位几何形状，这部分决定了它们的功能和特异性。根据结构，光谱和生化特性，根据每个家族经过深入研究的酶将它们分为三个大家族：黄嘌呤氧化酶，硫酸盐氧化酶和DMSO还原酶。此处概述了三个酶家族的代表性成员的X射线晶体学数据，重点是从结构数据得出的机理含义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号