Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)-chloroplatinum(II) with nucleosides and its biological activity

S.W.Annie Bligh; Alan Bashall; Christelle Garrud; Mary McPartlin; Nick Wardle; Ken White; Subhash Padhye; Vivek Barve; Gopal Kundu

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Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)-chloroplatinum(II) with nucleosides and its biological activity

机译：（C-（6-氨基甲基-吡啶-2-基）甲胺）-氯铂（II）与核苷的反应及其生物学活性

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~1H NMR and LC-ESI-MS studies of the interaction between nucleosides (adenosine,cytidine,guanosine,uridine and thymidine) and a monocation platinum(II) complex [Pt(C-(6-aminomethylpyridin-2-yl)methylamine)Cl]~+ (1) shows it forms platinum(II) complexes with A,G and C at pH 6 and with T and U at pH 9.The X-ray structure of 1 as the hydrated chloride salt shows extensive hydrogen bonding.Amongst a series of related complexes 1 shows a strong interaction with DNA,demonstrated by inhibition of binding by the intercalator ethidium bromide,and moderate cytotoxicity.The interaction with nucleosides and the structural data suggest that 1 disrupts the DNA structure by coordinate covalent interaction and hydrogen bonding rather than simple intercalation.

机译：核苷（腺苷，胞苷，鸟苷，尿苷和胸苷）与单阳离子铂（II）配合物[Pt（C-（6-氨基甲基吡啶-2-基）甲胺）之间相互作用的〜1H NMR和LC-ESI-MS研究Cl] +（1）显示它与pH为6的A，G和C以及pH为9的T和U形成铂（II）配合物。1的X射线结构为水合氯化物盐，显示出广泛的氢键。在一系列相关的配合物中，1与DNA具有很强的相互作用，表现为嵌入剂溴化乙锭抑制了结合，并具有中等的细胞毒性。与核苷的相互作用和结构数据表明1通过协调共价相互作用和氢破坏了DNA结构。结合而不是简单的插入。

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《Dalton transactions: An international journal of inorganic chemistry》 |2003年第2期|共5页
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S.W.Annie Bligh; Alan Bashall; Christelle Garrud; Mary McPartlin; Nick Wardle; Ken White; Subhash Padhye; Vivek Barve; Gopal Kundu;
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1. Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)-chloroplatinum(II) with nucleosides and its biological activity [J] . S.W.Annie Bligh, Alan Bashall, Christelle Garrud, Dalton transactions: An international journal of inorganic chemistry . 2003,第2期

机译：（C-（6-氨基甲基-吡啶-2-基）甲胺）-氯铂（II）与核苷的反应及其生物学活性
2. Synthesis of biologically active fused 1,4-oxathiin derivatives from 4-hydroxydithiocoumarins, arylacetylenes and dimethyl sulfoxide by Cu(Ⅰ)-catalyzed C-H functionalization and cross-dehydrogenative C-S coupling reactions [J] . Santa Mondal, Sabina Yashmin, Rashid Ali, Organic & biomolecular chemistry . 2021,第26期

机译：通过Cu（Ⅰ）通过Cu（Ⅰ） - 催化C-H官能化和交叉脱氢C-S偶联反应的生物活性熔融1,4-羟基甲蛋白衍生物的生物活性熔融1,4-氧血红素衍生物
3. Oximes of Nucleosides and Related Compounds: Synthesis, Reactions and Biological Activity [J] . Abele Edgars, Abele Ramona Current Organic Synthesis . 2018,第5期

机译：核苷和相关化合物的氧化物：合成，反应和生物活性
4. Formation of methylamines by the reaction of ammonia with surface methoxy species on zeolite H-Y and the siiicoaluminophosphate H-SAPO-34 [C] . Y. Jiang, J. Huang, W. Wang, The 40th Anniversary of International Zeolite Conference . 2007

机译：通过氨基沸石H-Y和SiIicoolumalophate H-SAPO-34反应形成甲胺的形成H-SAPO-34
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8. Recoil Reactions in Neutron-Activation AnalysisnI. The Szilard-Chalmers Effect Applied in the Analysis of Biological SamplesnII. Transfer of Activities from Container Material to Sample [R] . D. Brune 1965

机译：中子活化分析中的反冲反应。 szilard-Chalmers效应在生物样品分析中的应用。将活动从容器材料转移到样品

Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)-chloroplatinum(II) with nucleosides and its biological activity

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