The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities

Feng J.; Lu X.-M.; Wang G.; Du S.-Z.; Cheng Y.-F.

首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities

【24h】

The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities

机译：邻苯二酚和2,3-二羟基萘钼（vi）配合物的合成，表征及其体外抗癌活性的结构效应关系

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The reactions of (NH _4) _2Mo _2O _7·2H _2O with polyhydroxy phenols (catechol or 2,3-dihydroxynaphthalene) and ethylenediamine (en), trimethylenediamine (tn), 1,2-propanediamine (pn), triethylamine (Et _3N) respectively, in the mixed-solvent of MeCN-EtOH-amine, have resulted in five molybdenum(vi) complexes, (enH _2)[Mo VIO _3(cat)(en)] (1), (tnH _2)[Mo VIO _3(cat)(tn)] (2), (enH) _2[Mo VIO _2(cat) _2](en) 0.5 (3), (pnH _2) _2[Mo ~(VIO) _2(cat) _2] (4) and (HNEt _3) _2[Mo VIO _2(C _(10)H _8O _2) _2] (5), of which the structural features were investigated by X-ray diffraction. MTT assay tests indicated that their inhibition ratios against human cancer cells decreased in the order: (1) ≈ (2) > (3) ≈ (4) > (5), i.e. the activities decreased when the chelation number or the size of the aromatic ligand increased, which was consistent with the Gibbs free energies (ΔG) determined from theoretical computations by Gaussian 03. The mechanisms behind this trend were discussed preliminarily.

机译：（NH _4）_2Mo _2O _7·2H _2O与多羟基酚（邻苯二酚或2,3-二羟基萘）和乙二胺（en），三亚甲基二胺（tn），1,2-丙二胺（pn），三乙胺（Et _3N）的反应分别在MeCN-EtOH-胺的混合溶剂中产生了五种钼（vi）络合物，（enH _2）[Mo VIO _3（cat）（en）]（1），（tnH _2）[Mo VIO _3（cat）（tn）]（2），（enH）_2 [Mo VIO _2（cat）_2]（en）0.5（3），（pnH _2）_2 [Mo〜（VIO）_2（cat）_2] （4）和（HNEt _3）_2 [Mo VIO _2（C _（10）H _8O _2）_2]（5），其中的结构特征通过X射线衍射进行了研究。 MTT分析测试表明，它们对人类癌细胞的抑制率按以下顺序降低：（1）≈（2）>（3）≈（4）>（5），即，当螯合数或分子大小时活性降低。芳香族配体增加，这与高斯03的理论计算确定的吉布斯自由能（ΔG）一致。对此趋势的机理进行了初步讨论。

著录项

来源
《Dalton transactions: An international journal of inorganic chemistry》 |2012年第28期|共6页
作者
Feng J.; Lu X.-M.; Wang G.; Du S.-Z.; Cheng Y.-F.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities [J] . Feng J., Lu X.-M., Wang G., Dalton transactions: An international journal of inorganic chemistry . 2012,第28期

机译：邻苯二酚和2,3-二羟基萘钼（vi）配合物的合成，表征及其体外抗癌活性的结构效应关系
2. Soluble 2-substituted aminopyrido(2,3-d)pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity. [J] . Schroeder MC, Hamby JM, Connolly CJ, Journal of Medicinal Chemistry . 2001,第12期

机译：可溶性2-取代的氨基吡啶并（2,3-d）嘧啶-7-基脲对选定的酪氨酸激酶的结构活性关系和体外和体内抗癌活性的探索。
3. 2-Substituted aminopyrido(2,3-d)pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. [J] . Klutchko SR, Hamby JM, Boschelli DH, Journal of Medicinal Chemistry . 1998,第17期

机译：2-取代的氨基吡啶并（2,3-d）嘧啶7（8H）-ones。与所选酪氨酸激酶的结构活性关系以及体外和体内抗癌活性。
4. PEGylation of water soluble anticancer drug, Ara-C: Syntheses and in vitro in vivo Anti-Tumor Efficacy [C] . Yun H. Choe, Richard B. Greenwald, Charles D. Conover, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：水溶性抗癌药物Ara-C的PEG化：合成及体内外抗肿瘤功效
5. Syntheses and characterizations of monomeric molybdenum(VI) complexes with bidentate phosphine oxide ligands and dimeric and tetrameric molybdenum(V) clusters with benzoic acid and phosphinic acid derivatives, containing molybdenum oxide, molybdenum(2) dioxide (mu-oxygen) and molybdenum(4) tetroxide (mu3-oxygen) structural motifs [D] . Sreehari, Soumyashree 2010

机译：具有二齿膦氧化物配体的单体钼（VI）配合物以及具有苯甲酸和次膦酸衍生物的二聚和四聚钼（V）簇的合成和表征，其中包含氧化钼，二氧化钼（mu-oxygen）和钼（4））四氧化物（mu3-氧）结构基序
6. Preparation Spectroscopic Characterization Theoretical Investigations and In Vitro Anticancer Activity of Cd(II) Ni(II) Zn(II) and Cu(II) Complexes of 4(3 [O] . Ubale Panchsheela Ashok, Shiva Prasad Kollur, Nishad Anil, 2020

机译：CD（II）Ni（II）Zn（II）和Cu（II）复合物的制备光谱性表征理论研究和体外抗癌活性为4（3
7. BINUCLEATING AROYLHYDRAZONIC LIGANDS AND THEIR DICOPPER II COMPLEXES AS NEW CLASSES OF POTENTIAL ANTICANCER AGENTS: SYNTHESES, CHEMICAL CHARACTERIZATION AND BIOLOGICAL ACTIVITY [O] . JESICA PAOLA RADA ARIAS -1

机译：作为新类潜在抗癌剂的植物植物和其二墩II复合物：合成，化学表征和生物活性

The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure-effect relationship in their in vitro anticancer activities

摘要

著录项

相似文献

相关主题

期刊订阅