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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications
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Superparamagnetic nanoparticles as targeted probes for diagnostic and therapeutic applications

机译：超顺磁性纳米粒子作为诊断和治疗应用的靶向探针

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摘要

Superparamagnetic nanoparticles (NPs) have been attractive for medical diagnostics and therapeutics due to their unique magnetic properties and their ability to interact with various biomolecules of interest. The solution phase based chemical synthesis provides a near precise control on NP size, and monodisperse magnetic NPs with standard deviation in diameter of less than 10% are now routinely available. Upon controlled surface functionalization and coupling with fragments of DNA strands, proteins, peptides or antibodies, these NPs can be well-dispersed in biological solutions and used for drug delivery, magnetic separation, magnetic resonance imaging contrast enhancement and magnetic fluid hyperthermia. This Perspective reviews the common syntheses and controlled surface functionalization of monodisperse Fe_3O_4-based superparamagnetic NPs. It further outlines the exciting application potentials of these NPs in magnetic resonance imaging and drug delivery.
机译：超顺磁性纳米颗粒（NPs）由于其独特的磁性和与各种感兴趣的生物分子相互作用的能力而在医学诊断和治疗方面具有吸引力。基于溶液相的化学合成几乎可以精确控制NP的大小，现在可以常规使用直径标准偏差小于10％的单分散磁性NP。在受控的表面功能化并与DNA链，蛋白质，肽或抗体的片段偶联后，这些NP可以很好地分散在生物溶液中，并用于药物输送，磁分离，磁共振成像对比增强和磁流体热疗。该观点综述了单分散的基于Fe_3O_4的超顺磁性NP的一般合成和受控的表面官能化。它还概述了这些NP在磁共振成像和药物输送中令人兴奋的应用潜力。

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