...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Brain proteins that mind metals: a neurodegenerative perspective
【24h】

Brain proteins that mind metals: a neurodegenerative perspective

机译：介意金属的大脑蛋白质：神经变性的观点

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There are numerous neurodegenerative diseases but Alzheimer's disease and Parkinson's disease are the most common. In contrast, prion diseases are very rare but have sparked vast interest and study because of their potential threat. All three diseases have a common basis as they are linked to proteins that either aggregate or have break down products that aggregate. Even more strikingly, the three central proteins are metal binding proteins. Copper binds to both the prion protein and the amyloid precursor protein. Recently, alpha-synuclein has also been shown to bind copper. While study of the amyloid precursor protein (APP) and copper has not flourished since its discovery in the early 1990s and alpha-synuclein has only recently been a target for metallochemical investigation, the prion protein has been the centre of extensive research for the last decade. Therefore, recent insights into the metallochemistry of the prion protein are relevant to investigating APP and alpha-synuclein. This review considers what is known of the metallochemistry of all three proteins.
机译：神经退行性疾病很多，但阿尔茨海默氏病和帕金森氏病最常见。相比之下，diseases病毒疾病非常罕见，但由于其潜在的威胁而引起了广泛的兴趣和研究。这三种疾病都具有共同的基础，因为它们与聚集的蛋白质或分解的聚集产物相关。更为显着的是，这三个中心蛋白是金属结合蛋白。铜结合the病毒蛋白和淀粉样前体蛋白。最近，还显示了α-突触核蛋白结合铜。自从1990年代初发现淀粉样前体蛋白（APP）和铜以来，研究一直没有蓬勃发展，而α-突触核蛋白直到最近才成为金属化学研究的目标，,蛋白在过去十年中一直是广泛研究的中心。因此，对into病毒蛋白金属化学的最新见解与研究APP和α-突触核蛋白有关。这篇评论考虑了所有三种蛋白质的金属化学知识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号