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首页> 外文期刊>Der Hautarzt; Zeitschrift fuer Dermatologie, Venerologie, und verwandte Gebiete >Exercise-induced anaphylaxis [Anstrengungsinduzierte Anaphylaxie]
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Exercise-induced anaphylaxis [Anstrengungsinduzierte Anaphylaxie]

机译：运动引起的过敏反应[运动引起的过敏反应]

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摘要

Exercise-induced anaphylaxis is a mast cell dependent reaction, which is induced by allergen exposure in combination with physical activity. Typically, the reaction occurs within 2 hours after allergen exposure followed by physical activity. Not only food allergens but all kinds of allergens including drugs can induce this form of anaphylaxis. The clinical symptoms of exercise-induced anaphylaxis are the same as in any other type of anaphylaxis. Thus not only the skin and mucosa but also other organ systems like the lungs, cardiovascular system and gastrointestinal tract can be affected. The diagnostic work up should cover a detailed clinical history including the assessment of symptoms and possible trigger factors including suspected allergens. Besides classical allergy diagnostics like skin prick tests and specific IgE determination, tryptase should be measured for the differential diagnosis to exclude mast cell dependent diseases. The diagnosis of exercise-induced anaphylaxis is made by the means of a double-blind placebo-controlled provocation test. Both, a sufficient amount of allergen and of physical activity must be achieved for a valid test. After the diagnosis is made, patients should be extensively counseled and provided with an emergency kit including an epinephrine auto injector.
机译：运动引起的过敏反应是肥大细胞依赖性反应，是由过敏原暴露与体育锻炼相结合而引起的。通常，反应发生在接触过敏原后2小时内，然后进行体育锻炼。不仅食物过敏原，包括药物在内的各种过敏原都可以诱发这种过敏反应。运动引起的过敏反应的临床症状与任何其他类型的过敏反应相同。因此不仅可以影响皮肤和粘膜，还可以影响其他器官系统，例如肺，心血管系统和胃肠道。诊断检查应涵盖详细的临床病史，包括症状评估和可能的触发因素，包括可疑的过敏原。除了经典的过敏诊断方法（例如皮肤点刺试验和特定的IgE测定）外，还应测量类胰蛋白酶进行鉴别诊断，以排除肥大细胞依赖性疾病。运动诱发的过敏反应的诊断是通过双盲安慰剂对照激发试验进行的。有效的测试必须同时达到足够的过敏原和身体活动量。诊断后，应广泛咨询患者并提供包括肾上腺素自动注射器在内的急救包。

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