...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dermatologic surgery >Management of primary cutaneous melanoma of the hands and feet: a clinicoprognostic study.
【24h】

Management of primary cutaneous melanoma of the hands and feet: a clinicoprognostic study.

机译：手和脚原发性皮肤黑色素瘤的管理：临床预后研究。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Although acral lentiginous melanoma is the most common subtype of malignant melanoma in acral locations, the term acral melanoma (AM) has to be differentiated from the histopathologic description. OBJECTIVES: To characterize the clinical and pathologic features of patients with a primary AM and to elucidate whether the prognosis of patients with AM differs from that of those with melanoma at other sites (nonacral melanoma; NAM). PATIENTS AND METHOD: Over a 20-year period, a series of 822 consecutive patients with melanoma were recorded in the database. Clinical and follow-up data were retrieved from the melanoma register and prospectively analyzed. RESULTS: Eighty-nine patients had a malignant melanoma located on the acral sites of extremities. Breslow thickness and Clark level were found to be related to specific and disease-free survival. Breslow thickness greater than 4 mm was associated with greater risk of recurrence, and amelanosis and age of 60 and older were significantly associated with greater risk of death. Comparison of survival of patients with AM with that of those with NAM clearly showed that disease-free survival and overall survival were significantly lower in the former. CONCLUSION: Survival differences between patients with AM and NAM are due to differences in already known prognostic factors, probably as a consequence of a delay in the diagnosis in these locations.
机译：背景：尽管在肢端部位，恶性黑色素瘤是最常见的亚型黑色素瘤，但必须将其与组织病理学描述区分开。目的：鉴定原发性AM患者的临床和病理特征，并阐明AM患者的预后是否与其他部位（非髋部黑色素瘤; NAM）的预后不同。患者与方法：在20年的时间里，数据库中记录了822例连续的黑色素瘤患者。从黑色素瘤寄存器中检索临床和随访数据，并进行前瞻性分析。结果：89例患者的四肢尖部部位有恶性黑色素瘤。发现Breslow厚度和Clark水平与特异性和无病生存有关。大于4mm的Breslow厚度与复发风险更高，而60岁及60岁以上的黑斑病与死亡风险显着相关。 AM患者与NAM患者的生存率比较清楚地表明，前者的无病生存率和总生存率显着降低。结论：AM和NAM患者之间的生存差异是由于已知预后因素的差异，可能是由于这些位置的诊断延迟所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号