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首页> 外文期刊>Dermatologic surgery >Efficacy and Safety of Cross-Linked Carboxymethylcellulose Filler for Rejuvenation of the Lower Face: A 6-Month Prospective Open-Label Study
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Efficacy and Safety of Cross-Linked Carboxymethylcellulose Filler for Rejuvenation of the Lower Face: A 6-Month Prospective Open-Label Study

机译：交联羧甲基纤维素填充剂对下颌面年轻化的功效和安全性：为期6个月的前瞻性开放标签研究

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BACKGROUNDCross-linked carboxymethylcellulose (CMC) filler is a biosynthetic filler with very low antigenic risk.OBJECTIVETo assess the efficacy and safety of CMC filler in the rejuvenation of the lower face.MATERIALS AND METHODSTwo hundred eighty-seven procedures were performed in 174 patients: 115 nasolabial folds, 86 marionette lines, 29 bar codes, 14 cheek rhytides, and 43 lip rejuvenations. Results were evaluated at 3 (T1) and 6 months (T2) with photographic evaluation, Global Aesthetic Improvement Scale (GAIS), Modified Fitzpatrick Wrinkle Scale (MFWS) for nasolabial folds, Marionette Lines Grading Scale (MLGS), and Medicis Lip Fullness Scale (LFS).RESULTSGAIS was 2 in >91.05% of patients both in T1 and T2. MFWS score significantly improved at T1 (86.9% class 1, p < .001) and T2 (82.6% class 1, p < .001); in all patients in T1 and T2, median amelioration of MLGS was 2 1 and there was a significant amelioration of at least 1 grade in LSF in both upper and lower lips.CONCLUSIONThe use of CMC filler resulted in a significant and satisfactory amelioration of lower face aging signs with very low incidence of adverse events. Therefore, it should be considered a valid alternative to cross-linked hyaluronic acid fillers.
机译：背景交联羧甲基纤维素（CMC）填充剂是一种生物合成的填充剂，具有极低的抗原性风险。目的评估CMC填充剂在下面部修复中的功效和安全性。材料与方法在174例患者中进行了287例手术：115鼻唇沟，86个牵线木偶，29个条形码，14个面颊褶皱和43个唇部嫩肤。结果在3个（T1）和6个月（T2）进行了摄影评估，整体审美改善量表（GAIS），改良的Fitzpatrick鼻唇沟皱纹量表（MFWS），木偶线条分级量表（MLGS）和Medicis嘴唇丰满度量表（LFS）。在T1和T2中，> 91.05％的患者中，结果GAIS为2。 MFWS评分在T1（16.9级，p <.001）和T2（82.6％1级，p <.001）显着改善;在T1和T2的所有患者中，MLGS的中位改善为2 1，上下唇LSF的改善至少为1级。结论使用CMC填充剂可显着改善令人满意的下脸衰老迹象，不良事件发生率极低。因此，应该认为它是交联的透明质酸填料的有效替代品。

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