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Effect of intense pulsed light on rat skin

机译：强脉冲光对大鼠皮肤的影响

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Background Intense pulsed light (IPL) is widely used in treating skin conditions and has been reported to increase collagen and elastic fibers without damaging the epidermis. Objective To evaluate the effect of variation in the number of passes and intervals of IPL treatments on photorejuvenation in rats. Materials and Methods Groups of two rats each were exposed to two or four passes of an IPL source using a fluence of 30 J/cm 2 and a cut-off filter of 560 nm at 1- or 3-week intervals. The collagen and elastic fiber content in stained tissue biopsies and the thickness of the collagen fibers of IPL-irradiated and unexposed skin regions were compared. Results Collagen distribution and collagen fiber diameter was in IPL-irradiated than in control regions. The number of passes did not significantly affect the collagen fiber thickness, but the collagen fibers from the 3-week-interval groups were thicker than those of the 1-week-interval groups (p .001). Conclusion IPL increased dermal collagen fibers and collagen fiber diameter, suggesting efficacy in photorejuvenation and wrinkle reduction.
机译：背景技术强脉冲光（IPL）被广泛用于治疗皮肤疾病，并且据报道会增加胶原蛋白和弹性纤维而不会损害表皮。目的评估IPL治疗的通过次数和间隔时间变化对大鼠光子嫩肤的影响。材料和方法每组两只大鼠分别以30 J / cm 2的能量通量和560 nm的截止滤光片以1或3周的间隔暴露于IPL源的2或4次通过。比较染色组织活检中胶原蛋白和弹性纤维的含量，以及IPL辐照和未暴露的皮肤区域的胶原纤维的厚度。结果IPL照射的胶原蛋白分布和胶原纤维直径均高于对照组。通过的次数没有显着影响胶原纤维的厚度，但是间隔3周的组的胶原纤维比间隔1周的组的胶原纤维粗（p ＜.001）。结论IPL可增加真皮胶原纤维和胶原纤维直径，提示光子嫩肤和减少皱纹有效。

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